Researchers here argue for neural stem cells in the hypothalamus to support a youthful environment in many other tissues via secreted factors carried into circulation in exosomes. To the degree that this signaling falters with age, it contributes to the burden of aging and age-related dysfunction – though as ever it is challenging to assign a relative importance to this mechanism versus all of the others identified to date, or a firm place in a network of cause and consequence. I don’t think that describing either the signaling or its reduction with age as a program is helpful. We might expect component parts of a complex system to evolve a dependency on the behavior of other component parts. There are any number of well-established examples of the interdependence of internal organ function in the aging …
Arguing for Hypothalamic Neural Stem Cell Signaling to Support Function in Other Tissues
Researchers here argue for neural stem cells in the hypothalamus to support a youthful environment in many other tissues via secreted factors carried into circulation in exosomes. To the degree that this signaling falters with age, it contributes to the burden of aging and age-related dysfunction – though as ever it is challenging to assign a relative importance to this mechanism versus all of the others identified to date, or a firm place in a network of cause and consequence. I don’t think that describing either the signaling or its reduction with age as a program is helpful. We might expect component parts of a complex system to evolve a dependency on the behavior of other component parts. There are any number of well-established examples of the interdependence of internal organ function in the aging …