Assessment of Somatic Mosaicism as a Biomarker of Aging

Source https://www.fightaging.org/archives/2023/01/assessment-of-somatic-mosaicism-as-a-biomarker-of-aging/

Random mutations in stem cells lead to a pattern of mutations throughout the tissue supported by those stem cells, as daughter cells are imprinted with a particular combination of mutations based on the ancestor stem cell and the timing of cell division versus timing of mutations. In principle, one can take a sample of somatic cells and reverse engineer the progression of mutations in the underlying stem cell and progenitor cell populations from the variety and combination of mutations observed in the sample. That progression can then be used as the basis for a measure of chronological or biological age, a novel form of aging clock to join the many others derived from age-related changes in biological data.

<a href="https://doi.o…

What Do You Think?

comments