Source https://www.fightaging.org/archives/2019/07/both-extracellular-vesicles-and-secreted-proteins-can-spread-cellular-senescence/
The accumulation of senescent cells with age is one of the root causes of aging. Senescent cells never amount to more than a few percent of all cells, even in late life, but they secrete a mix of extracellular vesicles and various proteins that is inflammatory and disruptive to tissue function. This is known as the senescence-associated secretory phenotype, or SASP. Since senescent cells inflect harm through signaling, it doesn’t take many such cells to act as a contributing cause of age-related disease and organ dysfunction.
The research community is nowadays fully invested in the concept that senescent cells are a meaningf…
Source https://www.fightaging.org/archives/2019/07/both-extracellular-vesicles-and-secreted-proteins-can-spread-cellular-senescence/
The accumulation of senescent cells with age is one of the root causes of aging. Senescent cells never amount to more than a few percent of all cells, even in late life, but they secrete a mix of extracellular vesicles and various proteins that is inflammatory and disruptive to tissue function. This is known as the senescence-associated secretory phenotype, or SASP. Since senescent cells inflect harm through signaling, it doesn’t take many such cells to act as a contributing cause of age-related disease and organ dysfunction.
The research community is nowadays fully invested in the concept that senescent cells are a meaningf…
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