In recent years, researchers have shown that a single injected dose of CASIN, an inhibitor of CDC42, can improve immune function in old mice, resulting in a lasting gain in health and extended life span. CASIN appears to work by altering epigenetic state in the hematopoietic stem cell populations responsible for producing new immune cells. This is also observed to be the case in other stem cell populations. Raised levels of CDC42 are observed with aging, and have been <a href="https://www.fightaging.org/archives/2021/01/cdc42-inhibition-via-casin-as-a-possible-approach-to-rejuvenation-of-hematopoietic-stem-c…
CASIN Alters Epigenetic State to Produce Lasting Improvement in Aged Stem Cell Function
In recent years, researchers have shown that a single injected dose of CASIN, an inhibitor of CDC42, can improve immune function in old mice, resulting in a lasting gain in health and extended life span. CASIN appears to work by altering epigenetic state in the hematopoietic stem cell populations responsible for producing new immune cells. This is also observed to be the case in other stem cell populations. Raised levels of CDC42 are observed with aging, and have been <a href="https://www.fightaging.org/archives/2021/01/cdc42-inhibition-via-casin-as-a-possible-approach-to-rejuvenation-of-hematopoietic-stem-c…