Caveolin-1 Gene Therapy Reduces Cognitive Decline in an Alzheimer's Mouse Model

Source https://www.fightaging.org/archives/2025/06/caveolin-1-gene-therapy-reduces-cognitive-decline-in-an-alzheimers-mouse-model/

Researchers here assess a compensatory approach to the neurodegeneration of Alzheimer’s disease, meaning an enhancement of the ability of cells to operate in the face of damage rather than addressing the damage itself. This can inevitably only slow progression of the condition, and is not a path to a curative therapy. Nonetheless, tinkering with cell metabolism in order to slow disease progression is arguably the dominant approach to the development of new therapies. The research community needs to do better than this if we’re to see major advances in the treatment of aging and age-related conditions.

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by progressive synaptic loss and cogn…

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