Source https://www.fightaging.org/archives/2024/05/cellular-senescence-in-the-aging-kidney/
Much of past research into age-related disease involves looking at changes in gene expression in the diseased organ, a very low-level laundry list of alterations. This is somewhat decoupled from the approach of looking at changes in cell behavior, a high-level laundry list of alterations. A sizable fraction of life science research involves trying to make firm connections between these two sets of data, to better steer development efforts towards interfering in more relevant rather than less relevant mechanisms. Here, as an example of this sort of work, researchers link PAR2 expression in the kidney to cellular senescence in that organ. Senescent cells accumulate with age to produce <a href="https://www.fightaging.org/archives/2016/08/considering-the-mechanisms-and-treatment-of-inflamma…
Source https://www.fightaging.org/archives/2024/05/cellular-senescence-in-the-aging-kidney/
Much of past research into age-related disease involves looking at changes in gene expression in the diseased organ, a very low-level laundry list of alterations. This is somewhat decoupled from the approach of looking at changes in cell behavior, a high-level laundry list of alterations. A sizable fraction of life science research involves trying to make firm connections between these two sets of data, to better steer development efforts towards interfering in more relevant rather than less relevant mechanisms. Here, as an example of this sort of work, researchers link PAR2 expression in the kidney to cellular senescence in that organ. Senescent cells accumulate with age to produce <a href="https://www.fightaging.org/archives/2016/08/considering-the-mechanisms-and-treatment-of-inflamma…
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