Chronic Inflammatory Signaling in the Development of Aortic Aneurysms

Source https://www.fightaging.org/archives/2024/05/chronic-inflammatory-signaling-in-the-development-of-aortic-aneurysms/

An aneurysm is a weakened section of a major blood vessel wall that expands and remodels into a dilated bulge, vulnerable to rupture and subsequent death. Given that treatment often fails, prevention is of great interest to the research community. What are the contributing factors to the development of an aneurysm? Researchers here look at the contribution of inflammatory signaling, generally agreed upon to be central to the dysregulation of blood vessel tissue that leads to the creation of an aneurysm.

Abdominal aortic aneurysm (AAA) has been recognized as a serious chronic inflammatory degenerative aortic disease in recent years, and it is characterized by the progressive pathological dilatation of the abdominal aortic wall. Most patients who develop AAA are usually asymptomatic; however, when the aneurysm expands and ruptures,…

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