Source https://www.fightaging.org/archives/2024/07/clonal-hematopoiesis-of-indeterminate-potential-chip-accelerates-chronic-kidney-disease/
Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related state in which a hematopoietic stem cell suffers a mutation that gives it and its descendants replication advantages over their peers. Mutations of this nature spread throughout cell populations in an overlapping, layered way as they occur, a form of somatic mosaicism, but occurring in hematopoietic and immune cells. Like somatic mosaicism more generally, this has the look of a problem that should cause undesirable consequences. Drawing solid connections between CHIP and specific age-related diseases is a work in progress, however.
CHIP originated as the description of an early stage of dysfunction leading to leukemia<…
Source https://www.fightaging.org/archives/2024/07/clonal-hematopoiesis-of-indeterminate-potential-chip-accelerates-chronic-kidney-disease/
Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related state in which a hematopoietic stem cell suffers a mutation that gives it and its descendants replication advantages over their peers. Mutations of this nature spread throughout cell populations in an overlapping, layered way as they occur, a form of somatic mosaicism, but occurring in hematopoietic and immune cells. Like somatic mosaicism more generally, this has the look of a problem that should cause undesirable consequences. Drawing solid connections between CHIP and specific age-related diseases is a work in progress, however.
CHIP originated as the description of an early stage of dysfunction leading to leukemia<…
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