Source https://www.fightaging.org/archives/2025/06/considering-mutation-rates-in-cancer-risk-and-species-life-span/
Today’s open access paper merges discussion of a number of related topics. Firstly mutation rate in cancer tissue and its relationship to success in immunotherapy, secondly mutation rate in normal tissues as a risk factor for the development of cancer, and thirdly the radically different cancer risks exhibited by different mammalian species. It is well known that long-lived, large species have a much reduced cancer risk relative to short-lived, small species, and as researchers note here, this relationship is better mapped to mutation rates rather than to size or life span. Separately, within a species, cancer is clearly an age-related condition, where risk relates to the accumulated burden of somatic mutations within tissues.
C…
Source https://www.fightaging.org/archives/2025/06/considering-mutation-rates-in-cancer-risk-and-species-life-span/
Today’s open access paper merges discussion of a number of related topics. Firstly mutation rate in cancer tissue and its relationship to success in immunotherapy, secondly mutation rate in normal tissues as a risk factor for the development of cancer, and thirdly the radically different cancer risks exhibited by different mammalian species. It is well known that long-lived, large species have a much reduced cancer risk relative to short-lived, small species, and as researchers note here, this relationship is better mapped to mutation rates rather than to size or life span. Separately, within a species, cancer is clearly an age-related condition, where risk relates to the accumulated burden of somatic mutations within tissues.
C…
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