Decreased Flow of Interstitial Fluid in the Brain After 50 Years of Age

Source https://www.fightaging.org/archives/2024/06/decreased-flow-of-interstitial-fluid-in-the-brain-after-50-years-of-age/

A number of lines of evidence point to decreased fluid drainage from the brain into the body with aging. This drainage occurs through pathways such as the cribriform plate behind the nose and the comparatively recently discovered glymphatic system. Both of these fluid pathways are known to become dysfunctional with age. It is thought that the reduced drainage has a negative impact on the brain by allowing metabolic waste products to build up, such as the various forms of disruptive protein aggregates associated with neurodegenerative conditions.

Physiological age-related alterations in the interstitial flow in the brain, which plays an important role in waste pro…

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