Engineering Chimeric Antigen Receptor T Cells to Activate Only When Ultrasound Energy is Applied

Source https://www.fightaging.org/archives/2021/08/engineering-chimeric-antigen-receptor-t-cells-to-activate-only-when-ultrasound-energy-is-applied/

Providing a patient’s T cells with a receptor to match the surface characteristics of the patient’s cancer cells is proving to work quite well for some types of cancer. Unfortunately the match is never perfectly specific for cancerous cells, and chimeric antigen receptor T cells (CAR-T cells) can do a lot of damage to healthy tissue in many of the desired scenarios for treatment. Researchers here report on one of a number of presently explored approaches to limit the activation of CAR-T cells to only the cancerous tissue of interest, thereby making the therapy more viable.

New work addresses a longstanding problem in the field of cancer immunotherapy: how to make chimeric antigen receptor (CAR) T-cell therap…

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