Epigenetic Change with Age in Mice is Not Linear

Source https://www.fightaging.org/archives/2024/05/epigenetic-change-with-age-in-mice-is-not-linear/

Epigenetic marks such as DNA methylation control expression of genes and cell behavior. They change with age, a reflection of the processes of damage and dysfunction that occur with age. Researchers here focus on DNA methylation in one organ in mice to demonstrate that age-related changes are not linear over time. The individual goes through stages and phase transitions from one state of cellular behavior to another. This is worth considering when thinking about how epigenetic clocks that measure biological age might work in practice, especially when used as a way to evaluate the efficacy of potential rejuvenation therapies.

Analyzing the data of aging mouse colon<…