When looking at epidemiological evidence of the burden of amyloid-β and phosphorylated tau in the aging brain, and relating it to incidence and degree of neurodegenerative disease, it is worth bearing in mind that this doesn’t demonstrate causation. It remains the case that amyloid-β aggregation could be peripheral to the progression of Alzheimer’s disease, a side-effect of the primary mechanism, which could be something along the lines of chronic inflammation driven by cellular senescence or chronic inflammation <a href="https…
Evidence for Amyloid and Tau to Synergize to Make Neurodegeneration Worse
When looking at epidemiological evidence of the burden of amyloid-β and phosphorylated tau in the aging brain, and relating it to incidence and degree of neurodegenerative disease, it is worth bearing in mind that this doesn’t demonstrate causation. It remains the case that amyloid-β aggregation could be peripheral to the progression of Alzheimer’s disease, a side-effect of the primary mechanism, which could be something along the lines of chronic inflammation driven by cellular senescence or chronic inflammation <a href="https…