Source https://www.fightaging.org/archives/2020/02/exceptionally-long-lived-humans-exhibit-slower-epigenetic-aging-measured-by-dna-methlyation-clocks/
Epigenetic clocks are produced by examining age-related changes in DNA methylation, finding combinations of such changes that are consistent across populations, and predict chronological age. These clocks also predict mortality, in the sense that people with higher epigenetic than chronological age tend to have a higher mortality risk, or be more burdened by chronic age-related disease. The challenge here is that it remains very unclear as to what these epigenetic clocks are actually measuring, which of the underlying processes of aging they reflect, and to what degree. That makes it hard to use epigenetic clocks in any meaningful way – the results are not actionable.
There are other issues to be debugged as well. For example, that the first generation epigenetic clocks are <a href="https://www.fightaging.org/archives/2019/01/the-epigenetic-clock-d…
Source https://www.fightaging.org/archives/2020/02/exceptionally-long-lived-humans-exhibit-slower-epigenetic-aging-measured-by-dna-methlyation-clocks/
Epigenetic clocks are produced by examining age-related changes in DNA methylation, finding combinations of such changes that are consistent across populations, and predict chronological age. These clocks also predict mortality, in the sense that people with higher epigenetic than chronological age tend to have a higher mortality risk, or be more burdened by chronic age-related disease. The challenge here is that it remains very unclear as to what these epigenetic clocks are actually measuring, which of the underlying processes of aging they reflect, and to what degree. That makes it hard to use epigenetic clocks in any meaningful way – the results are not actionable.
There are other issues to be debugged as well. For example, that the first generation epigenetic clocks are <a href="https://www.fightaging.org/archives/2019/01/the-epigenetic-clock-d…
What Do You Think?
comments