Researchers here outline a mechanism by which excess fat tissue may accelerate the onset and progression of Alzheimer’s disease, by affecting the content of extracellular vesicles passing into the brain, that in turn increase the aggregation of misfolded amyloid-β that is characteristic of the early stages of the condition. Excess visceral fat also contributes to chronic inflammation via a range of different mechanisms, and Alzheimer’s disease is clearly an inflammatory condition. As is usually the case, det…
Extracellular Vesicles in Obese Individuals Increase the Aggregation of Amyloid-β in the Brain
Researchers here outline a mechanism by which excess fat tissue may accelerate the onset and progression of Alzheimer’s disease, by affecting the content of extracellular vesicles passing into the brain, that in turn increase the aggregation of misfolded amyloid-β that is characteristic of the early stages of the condition. Excess visceral fat also contributes to chronic inflammation via a range of different mechanisms, and Alzheimer’s disease is clearly an inflammatory condition. As is usually the case, det…