Blood pressure is dynamically regulated in response to circumstances and circadian rhythm. One of the issues arising with age is that this regulation is impaired, such as by the various mechanisms that stiffen blood vessels that include altered behavior of smooth muscle cells and cross-linking of the extracellular matrix. Researchers here show that dysregulation of diastolic blood pressure, in which normal variability is suppressed, can be distinctly correlated to progression of age-related cognitive decline. This is likely a reflection of shared underlying mechanisms that lead to both varied forms of vascular dysfunction in the brain an…
Failure to Regulate Diastolic Blood Pressure as a Contribution to Cognitive Decline
Blood pressure is dynamically regulated in response to circumstances and circadian rhythm. One of the issues arising with age is that this regulation is impaired, such as by the various mechanisms that stiffen blood vessels that include altered behavior of smooth muscle cells and cross-linking of the extracellular matrix. Researchers here show that dysregulation of diastolic blood pressure, in which normal variability is suppressed, can be distinctly correlated to progression of age-related cognitive decline. This is likely a reflection of shared underlying mechanisms that lead to both varied forms of vascular dysfunction in the brain an…