HDAC3 Inhibition Improves Memory Reconsolidation in Old Mice

Source https://www.fightaging.org/archives/2024/07/hdac3-inhibition-improves-memory-reconsolidation-in-old-mice/

Long term memories must be maintained by retrieval and update of their storage. Researchers here demonstrate that pharmacological inhibition of HDAC3 reduces issues with maintenance of memories in old mice. Interestingly the strategy is disruptive to initial memory formation in young mice, and this provides some additional insight into how this mechanisms of neurological aging functions. Understanding a great deal more of the fine detail regarding the functioning of mammalian memory will likely prove necessary to make large strides towards addressing this aspect of brain aging.

Long-term memories are not stored in a stable state but must be flexible and dynamic to maintain relevance in response to new information…

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