The mTOR protein forms complexes, of which mTORC1 is involved in nutrient sensing. Inhibiting mTORC1 mimics some of the effects of a low calorie diet, meaning cells will undertake greater maintenance and repair while also reducing activities that tend to produce molecular damage. The result of either low calorie intake or mTORC1 inhibition is a modestly slowed pace of aging, lesser degrees of dysfunction, lower chronic inflammation in later life, and so forth. Researchers here demonstrate that this can work in the other direction as well. They stimulate the activity of mTORC1 via <a href="https://en.wikipedia.org/wiki/RRAGC…
Increased mTORC1 Nutrient Sensing Shortens Life Span in Mice
The mTOR protein forms complexes, of which mTORC1 is involved in nutrient sensing. Inhibiting mTORC1 mimics some of the effects of a low calorie diet, meaning cells will undertake greater maintenance and repair while also reducing activities that tend to produce molecular damage. The result of either low calorie intake or mTORC1 inhibition is a modestly slowed pace of aging, lesser degrees of dysfunction, lower chronic inflammation in later life, and so forth. Researchers here demonstrate that this can work in the other direction as well. They stimulate the activity of mTORC1 via <a href="https://en.wikipedia.org/wiki/RRAGC…