Investigating the Mechanisms by which the Aged Gut Microbiome Provokes Chronic Inflammation

Source https://www.fightaging.org/archives/2024/05/investigating-the-mechanisms-by-which-the-aged-gut-microbiome-provokes-chronic-inflammation/

In recent years, it has become clear that the gut microbiome contributes meaningfully to long-term health, perhaps to much the same degree as exercise, diet, and other common lifestyle choices. Unlike those choices, the composition of the gut microbiome is more inscrutable, however. While commercial services employing 16S rRNA sequencing can cost-effectively list the microbial species present in the intestines, and their relative proportions, it remains a work in progress to (a) reliably connect differences in the list to pathologies of aging, and (b) reliably alter the gut microbiome in deterministic and lasting ways.

Which is not to say that we know nothing! It is clear that the relative proportions of the microbial species making up the gut microbiome change with age, and some of those changes provoke <a href="https://www.fightaging.org/archives/2016…

Source https://www.fightaging.org/archives/2024/05/investigating-the-mechanisms-by-which-the-aged-gut-microbiome-provokes-chronic-inflammation/

In recent years, it has become clear that the gut microbiome contributes meaningfully to long-term health, perhaps to much the same degree as exercise, diet, and other common lifestyle choices. Unlike those choices, the composition of the gut microbiome is more inscrutable, however. While commercial services employing 16S rRNA sequencing can cost-effectively list the microbial species present in the intestines, and their relative proportions, it remains a work in progress to (a) reliably connect differences in the list to pathologies of aging, and (b) reliably alter the gut microbiome in deterministic and lasting ways.

Which is not to say that we know nothing! It is clear that the relative proportions of the microbial species making up the gut microbiome change with age, and some of those changes provoke <a href="https://www.fightaging.org/archives/2016…

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