Source https://www.fightaging.org/archives/2025/07/loss-of-sting-signaling-dysregulates-lipid-metabolism/
The STING protein is a point of convergence for a range of molecular sensors in a cell that detect damage or infection. Triggering STING activity produces an inflammatory response. Unfortunately, cell dysfunctions characteristic of aging produce issues such as the escape of fragments of mitochondrial and nuclear DNA into the cell cytosol, where they trigger sensors evolved to detect infectious agents, and thus activate STING. This contributes to the chronic inflammation of aging. For this and other reasons, researchers are considering STING inhibition as a potential form of therapy for a range of inflammatory ag…
Source https://www.fightaging.org/archives/2025/07/loss-of-sting-signaling-dysregulates-lipid-metabolism/
The STING protein is a point of convergence for a range of molecular sensors in a cell that detect damage or infection. Triggering STING activity produces an inflammatory response. Unfortunately, cell dysfunctions characteristic of aging produce issues such as the escape of fragments of mitochondrial and nuclear DNA into the cell cytosol, where they trigger sensors evolved to detect infectious agents, and thus activate STING. This contributes to the chronic inflammation of aging. For this and other reasons, researchers are considering STING inhibition as a potential form of therapy for a range of inflammatory ag…
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