Source https://www.fightaging.org/archives/2022/03/modest-life-extension-in-mice-via-cd38-inhibition/
Nicotinamide adenine dinucleotide (NAD) in the context of aging and mitochondrial function has turned into a fairly energetic area of study. NAD is a crucial element in the mitochondrial production of the chemical energy store molecule adenosine triphosphate (ATP), but levels decline with age for a variety of reasons, and this contributes to loss of mitochondrial function. The characteristic changes in gene expression that take place with age lead to reduced production and recycling of NAD via various pathways. Further, CD38 acts to break down NAD and levels of CD38 increase with age.
Why does CD38 production increase with age? Research suggests that this is <a…
Source https://www.fightaging.org/archives/2022/03/modest-life-extension-in-mice-via-cd38-inhibition/
Nicotinamide adenine dinucleotide (NAD) in the context of aging and mitochondrial function has turned into a fairly energetic area of study. NAD is a crucial element in the mitochondrial production of the chemical energy store molecule adenosine triphosphate (ATP), but levels decline with age for a variety of reasons, and this contributes to loss of mitochondrial function. The characteristic changes in gene expression that take place with age lead to reduced production and recycling of NAD via various pathways. Further, CD38 acts to break down NAD and levels of CD38 increase with age.
Why does CD38 production increase with age? Research suggests that this is <a…
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