Reprogramming of adult cells occurs early in embryonic development, changing the adult germline cell into a pluripotent embryonic stem cell. This also removes epigenetic changes characteristic of age to rejuvenate cell functions, such as mitochondrial activity. A recipe for recreating this reprogramming process in any cell was discovered 20 years ago, and involves increased expression of the four Yamanaka factors. Over time, the interest of the scientific community has …
Progress in Separating Rejuvenation from Pluripotency in Cell Reprogramming
Reprogramming of adult cells occurs early in embryonic development, changing the adult germline cell into a pluripotent embryonic stem cell. This also removes epigenetic changes characteristic of age to rejuvenate cell functions, such as mitochondrial activity. A recipe for recreating this reprogramming process in any cell was discovered 20 years ago, and involves increased expression of the four Yamanaka factors. Over time, the interest of the scientific community has …