Proteases in the Biochemistry of Aging

Source https://www.fightaging.org/archives/2022/04/proteases-in-the-biochemistry-of-aging/

Proteases are an important category of molecular machinery in the cell, one of several responsible for breaking down proteins and other molecules into component parts that can be recycled. Proteases operate as a part of the cellular maintenance processes that remove excess or damaged and potentially damaging structures and proteins. The quality of this cellular maintenance influences cell and tissue function, and improved maintenance is a feature of many interventions, genetic and otherwise, that modestly slow aging in short-lived laboratory species. Looking at all proteases in the context of aging is a little broad for one paper, but the authors here outline the high level view and some specific examples.

Protein quality control ensures the degradation of damaged and misfolded proteins</…