Source https://www.fightaging.org/archives/2025/08/r-loop-dna-provokes-chronic-inflammation-via-cgas-sting/
Stretches of nuclear DNA can adopt a broad range of transient structural forms, guided by the complex feedback loops of epigenetic marks, decorating molecules added to and removed from DNA. Epigenetics as a form of control over gene expression is all a matter of structure: which regions are packaged up and inaccessible, which are accessible. Other processes can also have their effects on local structure of the DNA, however. Some of the resulting structural forms can be problematic, and might be thought of as damage or dysfunction or an unwanted side-effect of those processes operating on DNA. This is all fairly well described by the scientific community, with an established nomenclature for different structural features.
In this context, an R-loop …
Source https://www.fightaging.org/archives/2025/08/r-loop-dna-provokes-chronic-inflammation-via-cgas-sting/
Stretches of nuclear DNA can adopt a broad range of transient structural forms, guided by the complex feedback loops of epigenetic marks, decorating molecules added to and removed from DNA. Epigenetics as a form of control over gene expression is all a matter of structure: which regions are packaged up and inaccessible, which are accessible. Other processes can also have their effects on local structure of the DNA, however. Some of the resulting structural forms can be problematic, and might be thought of as damage or dysfunction or an unwanted side-effect of those processes operating on DNA. This is all fairly well described by the scientific community, with an established nomenclature for different structural features.
In this context, an R-loop …
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