Rare Individuals Exhibit Alzheimer's Pathology but No Symptoms

Source https://www.fightaging.org/archives/2024/05/rare-individuals-exhibit-alzheimers-pathology-but-no-symptoms/

In a tissue bank of more than 5,000 donated brains, researchers found 12 in which there were signs of Alzheimer’s disease pathology but for which the donors had exhibited none of the symptoms of Alzheimer’s disease. Here find a report on some of the biochemical differences found in these resilient brains; it is hoped that pursuing this line of research might aid in the understanding of the condition and strategies for the development of effective therapies.

Some individuals show a discrepancy between cognition and the amount of neuropathological changes characteristic for Alzheimer’s disease (AD). This phenomenon has been referred to as ‘resilience’. The molecular and cellular underpinnings of resilience remain poorly understood. To obtain an unbiased understandi…

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