Replication stress is the name given to disruptions to the process of DNA replication that takes place when a cell divides. The double stranded genome splits, unzipping into two single strands that are each provided with the complementary nucleotides in order to reform as two complete double-stranded copies. The rapidly moving point at which this unzipping takes place, where the two strands actually separate, is called the replication fork. It is a busy area of complex protein machinery, prone to failure and ongoing correction of failures. Unresolved failures lead to DNA damage, and DNA damage during this replication process c…
Replication Stress as an Underappreciated Contribution to Cellular Senescence and Aging
Replication stress is the name given to disruptions to the process of DNA replication that takes place when a cell divides. The double stranded genome splits, unzipping into two single strands that are each provided with the complementary nucleotides in order to reform as two complete double-stranded copies. The rapidly moving point at which this unzipping takes place, where the two strands actually separate, is called the replication fork. It is a busy area of complex protein machinery, prone to failure and ongoing correction of failures. Unresolved failures lead to DNA damage, and DNA damage during this replication process c…