The processes of autophagy act to remove damaged molecular machinery and structures in the cell. Autophagy becomes dysfunctional with age, however. This is likely downstream of underlying causes of aging that cause changes in gene expression that degrade the function of autophagic processes in one way or another. For example mitophagy, the clearance of damaged mitochondria by autophagy, is indirectly negatively impacted by changes in mitochondrial dynamics resulting from altered gene expression. Equally, age-related changes in gene expression <a href="https://www.fightaging.org/archives/2019/07/more-evidence-for-defects-in-the-formation-of-autophagosomes-to-be-important-in-the-age-related-de…
Restoration of Autophagy as a Goal in the Treatment of Aging
The processes of autophagy act to remove damaged molecular machinery and structures in the cell. Autophagy becomes dysfunctional with age, however. This is likely downstream of underlying causes of aging that cause changes in gene expression that degrade the function of autophagic processes in one way or another. For example mitophagy, the clearance of damaged mitochondria by autophagy, is indirectly negatively impacted by changes in mitochondrial dynamics resulting from altered gene expression. Equally, age-related changes in gene expression <a href="https://www.fightaging.org/archives/2019/07/more-evidence-for-defects-in-the-formation-of-autophagosomes-to-be-important-in-the-age-related-de…