The practice of calorie restriction, reducing calorie intake to as much as 40% below ad libitum intake while still maintaining optimal micronutrient levels, is well demonstrated to slow aging in a range of species. Relative extension of life span is smaller as species life span increases, however, for reasons that make sense from an evolutionary perspective. It is unclear as to how the observed, sweeping changes to metabolism conspire to produce this differing outcome, however. Evidence to date suggests that increased autophagy is the primary mechanism by which reduced calorie intake …
Reviewing Amino Acid Restriction as an Approach to Slow Aging
The practice of calorie restriction, reducing calorie intake to as much as 40% below ad libitum intake while still maintaining optimal micronutrient levels, is well demonstrated to slow aging in a range of species. Relative extension of life span is smaller as species life span increases, however, for reasons that make sense from an evolutionary perspective. It is unclear as to how the observed, sweeping changes to metabolism conspire to produce this differing outcome, however. Evidence to date suggests that increased autophagy is the primary mechanism by which reduced calorie intake …