A large portion of research into senescent cells in the context of degenerative aging is focused on how these cells fail to destroy themselves. Senescent cells are primed to enter the programmed cell death process of apoptosis, but various mechanisms hold this off. Sabotaging some of those mechanisms is an effective way to clear a sizable fraction of senescent cells in many old tissues, as demonstrated by the initial small molecule senolytic treatments, such as the <a href="https://www.fightaging.org/archives/2015/03/senolytic-drugs-to-kill-off-senescent-cells-and-thereby-slow-…
Reviewing the Mechanisms that Allow Senescent Cells to Resist Apoptosis
A large portion of research into senescent cells in the context of degenerative aging is focused on how these cells fail to destroy themselves. Senescent cells are primed to enter the programmed cell death process of apoptosis, but various mechanisms hold this off. Sabotaging some of those mechanisms is an effective way to clear a sizable fraction of senescent cells in many old tissues, as demonstrated by the initial small molecule senolytic treatments, such as the <a href="https://www.fightaging.org/archives/2015/03/senolytic-drugs-to-kill-off-senescent-cells-and-thereby-slow-…