Source https://www.fightaging.org/archives/2025/08/semaglutide-modestly-reduces-epigenetic-age-in-overweight-individuals/
There is some debate over whether GLP-1 receptor agonist drugs such as semaglutide can affect mechanisms relevant to aging independently of weight loss. GLP-1 receptors are present in many organs, including the brain, so it is not unreasonable to think that other outcomes may result from GLP-1 receptor agonism over and above reduced appetite and calorie intake. But do those outcomes slow aging to a meaningful degree in comparison to the effects of weight loss? That is where we should be appropriately skeptical.
Compelling mechanistic and epidemiological data indicates that excess visceral fat tissue accelerates aging,…
Source https://www.fightaging.org/archives/2025/08/semaglutide-modestly-reduces-epigenetic-age-in-overweight-individuals/
There is some debate over whether GLP-1 receptor agonist drugs such as semaglutide can affect mechanisms relevant to aging independently of weight loss. GLP-1 receptors are present in many organs, including the brain, so it is not unreasonable to think that other outcomes may result from GLP-1 receptor agonism over and above reduced appetite and calorie intake. But do those outcomes slow aging to a meaningful degree in comparison to the effects of weight loss? That is where we should be appropriately skeptical.
Compelling mechanistic and epidemiological data indicates that excess visceral fat tissue accelerates aging,…
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