Senescent Cells Accumulate Iron While Resisting the Consequent Ferroptosis

Source https://www.fightaging.org/archives/2025/09/senescent-cells-accumulate-iron-while-resisting-the-consequent-ferroptosis/

Ferroptosis is a form of programmed cell death driven by iron accumulation and involving extensive lipid peroxidation as the kill mechanism. Senescent cells accumulate with age to cause tissue dysfunction and are resistant to programmed cell death. Most present approaches to the selective destruction of senescent cells as a form of therapy involve some form of sabotage of one or more programmed cell death resistance mechanisms. Here, researchers show that senescent cells both accumulate iron and resist ferroptosis, which suggests potential targets for novel forms of senolytic drug capable of selectively destroying senescent cells with minimal harm to normal cells.

…

What Do You Think?

comments