Short Interspersed Nuclear Elements Expression as an Enabler of Nervous System Regeneration

Source https://www.fightaging.org/archives/2025/09/short-interspersed-nuclear-elements-expression-as-an-enabler-of-nervous-system-regeneration/

Why does the peripheral nervous system regenerate while the central nervous system does not? Both are composed of clusters of neurons linked by axons that can extend for as much as a few feet in the longest cases. Nerves are bundled axons. One of the approaches taken by researchers interested in applying regenerative medicine strategies to the central nervous system is to look for biochemical differences between peripheral nervous system neurons and axons versus central nervous system neurons and axons. There must exist specific differences that enable regeneration of peripheral nervous system axons or suppress regeneration of central nervous system axons. That doesn’t mean those dif…

Source https://www.fightaging.org/archives/2025/09/short-interspersed-nuclear-elements-expression-as-an-enabler-of-nervous-system-regeneration/

Why does the peripheral nervous system regenerate while the central nervous system does not? Both are composed of clusters of neurons linked by axons that can extend for as much as a few feet in the longest cases. Nerves are bundled axons. One of the approaches taken by researchers interested in applying regenerative medicine strategies to the central nervous system is to look for biochemical differences between peripheral nervous system neurons and axons versus central nervous system neurons and axons. There must exist specific differences that enable regeneration of peripheral nervous system axons or suppress regeneration of central nervous system axons. That doesn’t mean those dif…

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