Supplementing Amino Acids in the Ratio Needed for Collagen Production Modestly Reduces Epigenetic Age

Source https://www.fightaging.org/archives/2025/12/supplementing-amino-acids-in-the-ratio-needed-for-collagen-production-modestly-reduces-epigenetic-age/

Collagen supplementation has an interesting history, and as is often the case in these matters there is all too much hype and marketing in relation to the amount of actual data. But even looking at only the clinical trials, it seems likely that collagen supplementation can produce small beneficial results in a number of aspects of aging and age-related conditions. Here, researchers demonstrate in cells, worms, mice, and a human clinical trial that one can supplement the amino acids used in the production of collagen, in the right ratio, in order to produce these benefits. The human dose used was 8400 mg gycline, 1700 mg proline, and 1700 mg hydroxyproline, taken daily for six months. The biological age measure used…

Source https://www.fightaging.org/archives/2025/12/supplementing-amino-acids-in-the-ratio-needed-for-collagen-production-modestly-reduces-epigenetic-age/

Collagen supplementation has an interesting history, and as is often the case in these matters there is all too much hype and marketing in relation to the amount of actual data. But even looking at only the clinical trials, it seems likely that collagen supplementation can produce small beneficial results in a number of aspects of aging and age-related conditions. Here, researchers demonstrate in cells, worms, mice, and a human clinical trial that one can supplement the amino acids used in the production of collagen, in the right ratio, in order to produce these benefits. The human dose used was 8400 mg gycline, 1700 mg proline, and 1700 mg hydroxyproline, taken daily for six months. The biological age measure used…

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