The Longevity Gene Cisd2 Improves Liver Function in Aged Mice

Source https://www.fightaging.org/archives/2021/12/the-longevity-gene-cisd2-improves-liver-function-in-aged-mice/

Cisd2 is one of the few genes shown to regulate life span in both directions in animal models; less of it shortens life span, while overexpression extends life. Researches here focus on the effects of cisd2 on liver function in mice, showing that maintaining high levels of cisd2 expression into old age beneficially impacts a number of processes implicated in degenerative aging and liver disease. This isn’t the only organ in which cisd2 expression has measurable effects; other groups have studied cisd2 in the heart, for example.

The liver plays a pivotal role in mammalian aging. However, the mechanisms underlying liver aging remain unclear. Cisd2 is a pro-longevity gene in mice. Cisd2 mediates lifespan and healthspan via regulation o…

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