Variant Sequences that Reduce IL-6 Signaling Correlate with a Lower Risk of Cardiovascular Disease

Source https://www.fightaging.org/archives/2025/09/variant-sequences-that-reduce-il-6-signaling-correlate-with-a-lower-risk-of-cardiovascular-disease/

Researchers here analyze human genetic variants in the IL-6 gene to show that reduced IL-6 activity correlates with a lower risk of cardiovascular disease. Circulating IL-6 is generally thought of as a pro-inflammatory signal, and it is a target for the development of therapies. Chronic inflammation in later life is an important contribution to dysfunction and disease, and better control over this maladaptive inflammatory reaction to the cell and tissue damage that characterizes aging is a desirable goal.

Human genetics supports a causal involvement of IL-6 signaling in atherosclerotic cardiovascular disease, prompting the clinical development of anti-IL-6 therapies. Genetic evidence has historically focused…

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