Why Does Oral Microbiome Diversity Correlate with Late Life Cognitive Function?

Source https://www.fightaging.org/archives/2024/05/why-does-oral-microbiome-diversity-correlate-with-late-life-cognitive-function/

As the authors of today’s open access paper note, their study is not the first to find a correlation between the diversity of the oral microbiome and cognitive function. The relative numbers of different microbial species present in the mouth can be assessed using 16S rRNA sequencing, where different species have slightly different 16S rRNA gene sequences. Given low cost assays to categorize a microbiome, there is a growing interest in the contributions to function and dysfunction made by the various distinct microbiomes situated throughout the body: gut, skin, mouth, and so forth. In this case, a greater diversity of microbial species present in the mouth correlates with a lesser age-related loss of cognitive function. Why is this the case?

The most well researched mechanism is inflammation</…

Source https://www.fightaging.org/archives/2024/05/why-does-oral-microbiome-diversity-correlate-with-late-life-cognitive-function/

As the authors of today’s open access paper note, their study is not the first to find a correlation between the diversity of the oral microbiome and cognitive function. The relative numbers of different microbial species present in the mouth can be assessed using 16S rRNA sequencing, where different species have slightly different 16S rRNA gene sequences. Given low cost assays to categorize a microbiome, there is a growing interest in the contributions to function and dysfunction made by the various distinct microbiomes situated throughout the body: gut, skin, mouth, and so forth. In this case, a greater diversity of microbial species present in the mouth correlates with a lesser age-related loss of cognitive function. Why is this the case?

The most well researched mechanism is inflammation</…

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