β-hydroxybutyrate is also known as 3-Hydroxybutyrate. An increase in the circulating levels of this compound is thought to mediate some of the beneficial effects of exercise and calorie restriction. Here researchers supplement with β-hydroxybutyrate in mice, starting in mid-life, and observe an increase in median life span that is perhaps larger than one might expect for this intervention, similar to the outcome of rapamycin treatment. The researchers dive into some of the mechanisms involved, but one might think that an intervention of this sort will change most aspects of metabolism; it isn’t necessarily the case that those noted here are the most important…
β-Hydroxybutyrate Supplementation Slows Aging in Mice
β-hydroxybutyrate is also known as 3-Hydroxybutyrate. An increase in the circulating levels of this compound is thought to mediate some of the beneficial effects of exercise and calorie restriction. Here researchers supplement with β-hydroxybutyrate in mice, starting in mid-life, and observe an increase in median life span that is perhaps larger than one might expect for this intervention, similar to the outcome of rapamycin treatment. The researchers dive into some of the mechanisms involved, but one might think that an intervention of this sort will change most aspects of metabolism; it isn’t necessarily the case that those noted here are the most important…