Source https://www.fightaging.org/archives/2020/06/reuse-of-a-small-molecule-to-increase-autophagy-in-the-brain-is-trialed-for-alzheimers-disease/
Today I’ll point out an example of drug reuse and autophagy upregulation. The processes of autophagy are responsible for recycling molecular waste and broken cellular structures. Autophagy is upregulated in response to stress placed upon cells, whether by heat, cold, lack of nutrients, a toxic local environment, and so forth. This is beneficial to tissue function, health, and longevity, and thus there is considerable interest in the research community in producing therapies that boost the operation of autophagy. This hasn’t made a great deal of progress towards the clinic, but nonetheless in any of the sizable databases of small molecule compounds there are some that result in increased autophagy – the question is always whether the side-effects are tolerable.
The cancer research community in particula…
Source https://www.fightaging.org/archives/2020/06/reuse-of-a-small-molecule-to-increase-autophagy-in-the-brain-is-trialed-for-alzheimers-disease/
Today I’ll point out an example of drug reuse and autophagy upregulation. The processes of autophagy are responsible for recycling molecular waste and broken cellular structures. Autophagy is upregulated in response to stress placed upon cells, whether by heat, cold, lack of nutrients, a toxic local environment, and so forth. This is beneficial to tissue function, health, and longevity, and thus there is considerable interest in the research community in producing therapies that boost the operation of autophagy. This hasn’t made a great deal of progress towards the clinic, but nonetheless in any of the sizable databases of small molecule compounds there are some that result in increased autophagy – the question is always whether the side-effects are tolerable.
The cancer research community in particula…
Source https://zenhabits.net/itstime/
This is a painful time for so many of us. There is anger, outrage, pain, fear, racism, injustice, sadness, exhaustion — and it’s not just a recent thing, it goes back generations, as far as our country has existed.
It’s heartbreaking.
We need to let our hearts be broken by how minorities, but especially black people, are treated in this country. Let our hearts be broken by the fear they have to live through, the injustice they’ve suffered, the way they’re perceived by everyone else, the way they’re put down, incarcerated, stomped on, segregated, outcast, spit on, villainized, criminalized, demonized, slurred, patronized, marginalized, rejected, and put into poverty … and then blamed for all of that. Let our hearts be broken by how long this has been allowed to go on, how exhausted they must feel from all of it.
We start with the heartbreak, and then let this move us to…
Source https://zenhabits.net/itstime/
This is a painful time for so many of us. There is anger, outrage, pain, fear, racism, injustice, sadness, exhaustion — and it’s not just a recent thing, it goes back generations, as far as our country has existed.
It’s heartbreaking.
We need to let our hearts be broken by how minorities, but especially black people, are treated in this country. Let our hearts be broken by the fear they have to live through, the injustice they’ve suffered, the way they’re perceived by everyone else, the way they’re put down, incarcerated, stomped on, segregated, outcast, spit on, villainized, criminalized, demonized, slurred, patronized, marginalized, rejected, and put into poverty … and then blamed for all of that. Let our hearts be broken by how long this has been allowed to go on, how exhausted they must feel from all of it.
We start with the heartbreak, and then let this move us to…
Source http://feedproxy.google.com/~r/tinybuddha/~3/W_2TgLBzkFo/
“Everything you ever wanted is one step outside your comfort zone.” ~Unknown
We’ve all seen this quote or similar ones. All the magic, growth, and transformation seem to happen there. Not everything that happens outside the comfort zone is magical though. So, when we go wandering, leaving the safe shores, we also need to be realistic and aware that mixed in with the good, there’s also potential pain and discomfort waiting for us.
Being aware of this, how can we still motivate ourselves to try something new and to step outside our comfort zone?
On the one hand, I love variety and I easily get bored. On the other hand, I am also risk-averse and easily scared. The latter doesn’t exactly lend itself to living the great adventures of life, whereas the former often acts as motiv…
Source http://feedproxy.google.com/~r/tinybuddha/~3/W_2TgLBzkFo/
“Everything you ever wanted is one step outside your comfort zone.” ~Unknown
We’ve all seen this quote or similar ones. All the magic, growth, and transformation seem to happen there. Not everything that happens outside the comfort zone is magical though. So, when we go wandering, leaving the safe shores, we also need to be realistic and aware that mixed in with the good, there’s also potential pain and discomfort waiting for us.
Being aware of this, how can we still motivate ourselves to try something new and to step outside our comfort zone?
On the one hand, I love variety and I easily get bored. On the other hand, I am also risk-averse and easily scared. The latter doesn’t exactly lend itself to living the great adventures of life, whereas the former often acts as motiv…
Source https://minimalistbaker.com/easy-no-bake-chocolate-chip-cookies/
When you’re craving chocolate chip cookies but want them FAST, this 5-ingredient no bake recipe is just the solution.
Dates, almond flour, vanilla, sea salt, and chocolate chips combine to make one seriously chocolatey, salty-sweet dessert that’s a total crowd pleaser.
Plus, they’re naturally vegan, gluten- and grain-free, and customizable! Let us show you how!
It starts with pulsing pitted dates in a food processor until they break up into smal…
Source https://minimalistbaker.com/easy-no-bake-chocolate-chip-cookies/
When you’re craving chocolate chip cookies but want them FAST, this 5-ingredient no bake recipe is just the solution.
Dates, almond flour, vanilla, sea salt, and chocolate chips combine to make one seriously chocolatey, salty-sweet dessert that’s a total crowd pleaser.
Plus, they’re naturally vegan, gluten- and grain-free, and customizable! Let us show you how!
It starts with pulsing pitted dates in a food processor until they break up into smal…
Source https://www.foodpolitics.com/2020/06/a-dog-with-coronavirus/
Interested as I am in pet food and the effects of coronavirus on what’s happening with these products, I was fascinated to come across this item:
Confirmation of COVID-19 in Pet Dog in New York.
Uh oh. We knew that cats and tigers could get this disease but dogs were considered safe from it.
The big question: can pets transmit?
I’m guessing yes, although maybe not easily.
…
Source https://www.foodpolitics.com/2020/06/a-dog-with-coronavirus/
Interested as I am in pet food and the effects of coronavirus on what’s happening with these products, I was fascinated to come across this item:
Confirmation of COVID-19 in Pet Dog in New York.
Uh oh. We knew that cats and tigers could get this disease but dogs were considered safe from it.
The big question: can pets transmit?
I’m guessing yes, although maybe not easily.
…