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A Possible Feedback Loop Between Abnormal Brain Activity and Neuroinflammation in Alzheimer's Disease

Source https://www.fightaging.org/archives/2021/11/a-possible-feedback-loop-between-abnormal-brain-activity-and-neuroinflammation-in-alzheimers-disease/

Researchers here put forward an interesting view of the progression of Alzheimer’s disease, in which abnormal modes of brain activity are part of a feedback loop that between inflammation and pathological protein aggregation. Evidence strongly suggests that chronic inflammation in brain tissue is an important component of neurodegenerative conditions, and the aggregation of altered proteins such as tau is both caused by inflammation and contributes to it. It is interesting to see …

Source https://www.fightaging.org/archives/2021/11/a-possible-feedback-loop-between-abnormal-brain-activity-and-neuroinflammation-in-alzheimers-disease/

Researchers here put forward an interesting view of the progression of Alzheimer’s disease, in which abnormal modes of brain activity are part of a feedback loop that between inflammation and pathological protein aggregation. Evidence strongly suggests that chronic inflammation in brain tissue is an important component of neurodegenerative conditions, and the aggregation of altered proteins such as tau is both caused by inflammation and contributes to it. It is interesting to see …

Glutathione Delivery via Iontophoresis Increases Gluthathione Levels in Blood Samples

Source https://www.fightaging.org/archives/2021/11/glutathione-delivery-via-iontophoresis-increases-gluthathione-levels-in-blood-samples/

Glutathione is a mitochondrial antioxidant, and additional antioxidant capacity in mitochondria appears to be beneficial to long-term health, improving mitochondrial function and overall health. Mitochondria conduct the energetic process of producing ATP, used to power the cell, with a flux of oxidative molecules as a side-effect. With age, mitochondria tend to become less efficient and produce more oxidizing molecules, harmful to the cell. Glutathione levels decline with age, which may contribute to this age-related <a href="https://www.fightaging.org/archives/2017/12/reviewing-the-mitochondrial-contribution-to-aging-and-age-rel…

Source https://www.fightaging.org/archives/2021/11/glutathione-delivery-via-iontophoresis-increases-gluthathione-levels-in-blood-samples/

Glutathione is a mitochondrial antioxidant, and additional antioxidant capacity in mitochondria appears to be beneficial to long-term health, improving mitochondrial function and overall health. Mitochondria conduct the energetic process of producing ATP, used to power the cell, with a flux of oxidative molecules as a side-effect. With age, mitochondria tend to become less efficient and produce more oxidizing molecules, harmful to the cell. Glutathione levels decline with age, which may contribute to this age-related <a href="https://www.fightaging.org/archives/2017/12/reviewing-the-mitochondrial-contribution-to-aging-and-age-rel…

12 Dairy-Free Recipes That Are Just as Rich as the Real Deal

Source https://greatist.com/eat/dairy-free-recipes

Cutting out dairy can seem next to impossible when you think about the foods you’ll have to give up, from cheesy slices of pizza to ice cream and cheese plates.

But as dairy-free diets have grown in popularity, it’s become easier and easier to find substitutes to use when cooking or snacking. With the right shopping list, dairy-free doesn’t have to be a drag. Promise.

These dairy-free recipes use everything from nutritional yeast to coconut milk to mimic the rich, creamy, or savory taste you want without any of the lactose or animal byproducts you may be trying to avoid.

1. Vegan kale Caesar salad

Vegan Kale Caesar Salad

Love a good Caesar salad? You can still have one without a speck of Parm or mayo in sig…

Source https://greatist.com/eat/dairy-free-recipes

Cutting out dairy can seem next to impossible when you think about the foods you’ll have to give up, from cheesy slices of pizza to ice cream and cheese plates.

But as dairy-free diets have grown in popularity, it’s become easier and easier to find substitutes to use when cooking or snacking. With the right shopping list, dairy-free doesn’t have to be a drag. Promise.

These dairy-free recipes use everything from nutritional yeast to coconut milk to mimic the rich, creamy, or savory taste you want without any of the lactose or animal byproducts you may be trying to avoid.

1. Vegan kale Caesar salad

Vegan Kale Caesar Salad

Love a good Caesar salad? You can still have one without a speck of Parm or mayo in sig…

Fight Aging! Newsletter, November 8th 2021

Source https://www.fightaging.org/archives/2021/11/fight-aging-newsletter-november-8th-2021/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/

Contents

  • How to Plan and Carry Out a Simple Self-Experiment, a Single Person Trial of Khavinson Peptides for Thymic Reg…

Source https://www.fightaging.org/archives/2021/11/fight-aging-newsletter-november-8th-2021/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/

Contents

  • How to Plan and Carry Out a Simple Self-Experiment, a Single Person Trial of Khavinson Peptides for Thymic Reg…

Finding Cautions in the Ease with which it is Possible to Create Epigenetic Clocks

Source https://www.fightaging.org/archives/2021/11/finding-cautions-in-the-ease-with-which-it-is-possible-to-create-epigenetic-clocks/

In recent years, researchers have established that machine learning approaches can be used to produce any number of clocks from biological data that shifts with age, finding patterns that match chronological or biological age to a great enough accuracy to suggest that they can be useful assays for the assessment of potential age-slowing and rejuvenating therapies. It remains an open question as to whether and how exactly the assessed patterns correlate to the specific forms of molecular damage that cause aging, or to any of the specific downstream consequences of that damage. Scientists here raise the possibility that much of the epigenetic change of aging may not in fact be as use…

Source https://www.fightaging.org/archives/2021/11/finding-cautions-in-the-ease-with-which-it-is-possible-to-create-epigenetic-clocks/

In recent years, researchers have established that machine learning approaches can be used to produce any number of clocks from biological data that shifts with age, finding patterns that match chronological or biological age to a great enough accuracy to suggest that they can be useful assays for the assessment of potential age-slowing and rejuvenating therapies. It remains an open question as to whether and how exactly the assessed patterns correlate to the specific forms of molecular damage that cause aging, or to any of the specific downstream consequences of that damage. Scientists here raise the possibility that much of the epigenetic change of aging may not in fact be as use…

Get Fur-Real Results: Your Guide to Laser Hair Removal Aftercare

Source https://greatist.com/health/laser-hair-removal-aftercare

On a quest for the smoothest method for permanent hair removal? So far, laser hair removal is the most effective method out there for gradually turning furry limbs into supple, seal-like ones.

So, if you’re ready to commit to (semi-) hairlessness, here’s what to expect after you go under the lasers.

What do I do after laser hair removal?

Laser hair removal is typically conducted by a dermatologist. The process works via concentrated light beams that target hair follicles and break down their roots.

Whether you’re opting to zap your panty line or your pits, here’s what to do po…

Source https://greatist.com/health/laser-hair-removal-aftercare

On a quest for the smoothest method for permanent hair removal? So far, laser hair removal is the most effective method out there for gradually turning furry limbs into supple, seal-like ones.

So, if you’re ready to commit to (semi-) hairlessness, here’s what to expect after you go under the lasers.

What do I do after laser hair removal?

Laser hair removal is typically conducted by a dermatologist. The process works via concentrated light beams that target hair follicles and break down their roots.

Whether you’re opting to zap your panty line or your pits, here’s what to do po…

How I’ve Released the Heavy Weight of My Persistent Guilt

Source http://feedproxy.google.com/~r/tinybuddha/~3/KYTR3fVltfw/

“No amount of guilt can change the past and no amount of worry can change the future.” ~Umar

Every emotion is felt by the body in a different way.

Pain can be sharp and biting, with a desire to lash out. Anxiety can also be sharp and biting, but with a desire to lash within. Sadness can feel like your body turning into stone, making every step seem impossible.

We all feel these emotions at times, but holding onto them is what causes damage. We must learn to shed them, as any “negative” emotion, if held on for too long, can release toxins that destroy our bodies over time.

Often, emotions like anger and anxiety and even sadness are symptoms of a more destructive emotion that destroys the human spirit. Robs us of our joy. And is unquestionably the heaviest…

Source http://feedproxy.google.com/~r/tinybuddha/~3/KYTR3fVltfw/

“No amount of guilt can change the past and no amount of worry can change the future.” ~Umar

Every emotion is felt by the body in a different way.

Pain can be sharp and biting, with a desire to lash out. Anxiety can also be sharp and biting, but with a desire to lash within. Sadness can feel like your body turning into stone, making every step seem impossible.

We all feel these emotions at times, but holding onto them is what causes damage. We must learn to shed them, as any “negative” emotion, if held on for too long, can release toxins that destroy our bodies over time.

Often, emotions like anger and anxiety and even sadness are symptoms of a more destructive emotion that destroys the human spirit. Robs us of our joy. And is unquestionably the heaviest…

Everything is a Practice

Source https://zenhabits.net/practiceground/

By Leo Babauta

I have a client who has completely changed his life — it’s been a complete transformation, and it is breathtaking.

One of the most powerful things he’s brought into his life is the practice of self-compassion. It changed everything, once he started bringing this into what he did.

But one of the next most powerful things he created for himself is the view that Everything is a Practice.

Man, what a ridiculously valuable way to frame our lives!

Every difficulty that comes up is simply something to practice with.

Every frustration with another person is a practice ground, and the other person becomes your teacher. Bow to them with gratitude!

Normally, we think of these difficulties and frustrations as something wrong with us, the other person, or the world. With this kind of view, every failure is another reason to feel bad about ourse…

Source https://zenhabits.net/practiceground/

By Leo Babauta

I have a client who has completely changed his life — it’s been a complete transformation, and it is breathtaking.

One of the most powerful things he’s brought into his life is the practice of self-compassion. It changed everything, once he started bringing this into what he did.

But one of the next most powerful things he created for himself is the view that Everything is a Practice.

Man, what a ridiculously valuable way to frame our lives!

Every difficulty that comes up is simply something to practice with.

Every frustration with another person is a practice ground, and the other person becomes your teacher. Bow to them with gratitude!

Normally, we think of these difficulties and frustrations as something wrong with us, the other person, or the world. With this kind of view, every failure is another reason to feel bad about ourse…

How I Find the Courage to Keep Jumping (Even Though the Net Never Catches Me)

Source http://feedproxy.google.com/~r/tinybuddha/~3/Uvm_ngX4J9Y/

“The future never comes. Life is always now.” ~Eckhart Tolle

“Jump, and the net will catch you.” “Leap, and the net will appear.”

This piece of writing is to make a case for the following argument: there is NO net.

Before I put forward my reasoning, please bear with me for a moment while my ego rattles off the times I have jumped (but the net never appeared).

  1. I quit my well-paid marketing role and traveled across the world to pursue a humanitarian dream job. I failed at the job interview and was jobless and in despair in a foreign land.
  2. I invested some of my savings into launching an online e-commerce site selling organic products but was diagnosed with blood cancer shortly after launch and had to give it up.
  3. I threw mys…

Source http://feedproxy.google.com/~r/tinybuddha/~3/Uvm_ngX4J9Y/

“The future never comes. Life is always now.” ~Eckhart Tolle

“Jump, and the net will catch you.” “Leap, and the net will appear.”

This piece of writing is to make a case for the following argument: there is NO net.

Before I put forward my reasoning, please bear with me for a moment while my ego rattles off the times I have jumped (but the net never appeared).

  1. I quit my well-paid marketing role and traveled across the world to pursue a humanitarian dream job. I failed at the job interview and was jobless and in despair in a foreign land.
  2. I invested some of my savings into launching an online e-commerce site selling organic products but was diagnosed with blood cancer shortly after launch and had to give it up.
  3. I threw mys…

No Lyes, Please: Is Sodium Hydroxide Safe in Skin Care?

Source https://greatist.com/health/sodium-hydroxide-skin-care

Sodium hydroxide is a popular ingredient in tons of skin care products that can seem hella scary due to its caustic nature. But while there’s def some risk, it’s generally safe if you spot sodium hydroxide in your fave cleanser.

Here’s the scoop on why sodium hydroxide shouldn’t actually burn your face off when used in skin care products.

Sodium hydroxide in skin care 101

What does it do? Sodium hydroxide helps stabilize and maintain a skin care product’s pH. It also helps fats and oils form into soap via saponification.

What skin care products use it? You’ll find sodium hydroxide in makeup, cleansers, and soaps.

What are the side effects? In high concentrations, sodium hydroxide can cause chemical burns, <a href="/health/hives-on-black-skin/" data-type="pos…

Source https://greatist.com/health/sodium-hydroxide-skin-care

Sodium hydroxide is a popular ingredient in tons of skin care products that can seem hella scary due to its caustic nature. But while there’s def some risk, it’s generally safe if you spot sodium hydroxide in your fave cleanser.

Here’s the scoop on why sodium hydroxide shouldn’t actually burn your face off when used in skin care products.

Sodium hydroxide in skin care 101

What does it do? Sodium hydroxide helps stabilize and maintain a skin care product’s pH. It also helps fats and oils form into soap via saponification.

What skin care products use it? You’ll find sodium hydroxide in makeup, cleansers, and soaps.

What are the side effects? In high concentrations, sodium hydroxide can cause chemical burns, <a href="/health/hives-on-black-skin/" data-type="pos…

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