MANF Upregulation in Macrophages Improves Muscle Regeneration in Old Mice

Source https://www.fightaging.org/archives/2023/03/manf-upregulation-in-macrophages-improves-muscle-regeneration-in-old-mice/

Regeneration following injury is an intricate, coordinated dance between stem cells, various types of somatic cell, and immune cells. Age-related changes in any of those cell populations may contribute to the declining ability to heal injuries observed in later life. Researchers here identify a specific change in the innate immune cells called macrophages that produces a significant impairment in wound healing in mice. This may prove to the basis for therapies to improve regeneration in older people, time will tell.

As our organism ages, the muscles lose the capacity to regenerate. Researchers have found a protein that regulates the function of a subset of immune …

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