Source https://www.fightaging.org/archives/2023/03/modeling-a-cellular-cascade-of-alzheimers-disease/
Alzheimer’s disease is complex and puzzling, and massively funded, high-profile efforts to find treatments for the condition have been failing for decades. The research community has focused on clearance of amyloid-β, as this protein accumulates and misfolds in Alzheimer’s patients. Yet some old individuals exhibit high levels of amyloid-β and do not suffer Alzheimer’s, while clearance of extracellular amyloid-β fails to meaningfully improve the condition of patients. It may be that intracellular amyloid-β is the real target…
Source https://www.fightaging.org/archives/2023/03/modeling-a-cellular-cascade-of-alzheimers-disease/
Alzheimer’s disease is complex and puzzling, and massively funded, high-profile efforts to find treatments for the condition have been failing for decades. The research community has focused on clearance of amyloid-β, as this protein accumulates and misfolds in Alzheimer’s patients. Yet some old individuals exhibit high levels of amyloid-β and do not suffer Alzheimer’s, while clearance of extracellular amyloid-β fails to meaningfully improve the condition of patients. It may be that intracellular amyloid-β is the real target…
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