DDX5 Can Form Prion-Like Aggregates in the Aging Brain

Source https://www.fightaging.org/archives/2024/06/ddx5-can-form-prion-like-aggregates-in-the-aging-brain/

A prion is a protein that can misfold in a way that encourages other molecules of the same protein to misfold in the same way. It can thus spread like a pathogen through cells and tissues, producing pathological changes in its wake. “Prion” is a term used inconsistently in the research community, as the very well researched amyloid-β and α-synuclein, drivers of neurodegenerative conditions, have prion-like properties but are rarely referred to as prions. So in one sense, yes, there are indeed prions in the aging brain, spreading and causing harm. Here, researchers look into the protein DDX5 in s…

Source https://www.fightaging.org/archives/2024/06/ddx5-can-form-prion-like-aggregates-in-the-aging-brain/

A prion is a protein that can misfold in a way that encourages other molecules of the same protein to misfold in the same way. It can thus spread like a pathogen through cells and tissues, producing pathological changes in its wake. “Prion” is a term used inconsistently in the research community, as the very well researched amyloid-β and α-synuclein, drivers of neurodegenerative conditions, have prion-like properties but are rarely referred to as prions. So in one sense, yes, there are indeed prions in the aging brain, spreading and causing harm. Here, researchers look into the protein DDX5 in s…

More on PI3K Inhibitors as Senolytic Drugs

Source https://www.fightaging.org/archives/2024/06/more-on-pi3k-inhibitors-as-senolytic-drugs/

Senolytic drugs selectively clear senescent cells from aged tissues. They are variably effective in different stages of cellular senescence, origins of cellular senescence, and tissue types, as senescent cells vary widely in the details of their biochemistry. We might expect a near future clinical marketplace to feature a dozen or more senolytic therapies, each of which is tailored to specific circumstances and age-related conditions. One of the interesting use cases is to destroy the senescent cancer cells that remain in the body after chemotherapy and other forms of cancer treatment. This will likely require somewhat different senolytics from those used to clear cells …

Source https://www.fightaging.org/archives/2024/06/more-on-pi3k-inhibitors-as-senolytic-drugs/

Senolytic drugs selectively clear senescent cells from aged tissues. They are variably effective in different stages of cellular senescence, origins of cellular senescence, and tissue types, as senescent cells vary widely in the details of their biochemistry. We might expect a near future clinical marketplace to feature a dozen or more senolytic therapies, each of which is tailored to specific circumstances and age-related conditions. One of the interesting use cases is to destroy the senescent cancer cells that remain in the body after chemotherapy and other forms of cancer treatment. This will likely require somewhat different senolytics from those used to clear cells …

Increased mTORC1 Nutrient Sensing Shortens Life Span in Mice

Source https://www.fightaging.org/archives/2024/06/increased-mtorc1-nutrient-sensing-shortens-life-span-in-mice/

The mTOR protein forms complexes, of which mTORC1 is involved in nutrient sensing. Inhibiting mTORC1 mimics some of the effects of a low calorie diet, meaning cells will undertake greater maintenance and repair while also reducing activities that tend to produce molecular damage. The result of either low calorie intake or mTORC1 inhibition is a modestly slowed pace of aging, lesser degrees of dysfunction, lower chronic inflammation in later life, and so forth. Researchers here demonstrate that this can work in the other direction as well. They stimulate the activity of mTORC1 via <a href="https://en.wikipedia.org/wiki/RRAGC…

Source https://www.fightaging.org/archives/2024/06/increased-mtorc1-nutrient-sensing-shortens-life-span-in-mice/

The mTOR protein forms complexes, of which mTORC1 is involved in nutrient sensing. Inhibiting mTORC1 mimics some of the effects of a low calorie diet, meaning cells will undertake greater maintenance and repair while also reducing activities that tend to produce molecular damage. The result of either low calorie intake or mTORC1 inhibition is a modestly slowed pace of aging, lesser degrees of dysfunction, lower chronic inflammation in later life, and so forth. Researchers here demonstrate that this can work in the other direction as well. They stimulate the activity of mTORC1 via <a href="https://en.wikipedia.org/wiki/RRAGC…

An Artificial Lymph Node to Guide T Cells to Attack Specific Targets, Such as Cancers

Source https://www.fightaging.org/archives/2024/06/an-artificial-lymph-node-to-guide-t-cells-to-attack-specific-targets-such-as-cancers/

Lymph nodes are points of coordination for the immune system, where T cells of the adaptive immune system are presented with antibodies that match target molecules, in effect given instructions as to what to attack next. Calling a structure made of biomaterials and decorated with antibodies an “artificial lymph node” does get the point across, but this is a far cry from, say, a lymph node organoid that shares a similar structure and set of cell populations with a natural lymph node. Still, the artificial structure does serve this one purpose, to instruct T cells. Researchers here envisage implanting a lymph node substitute as a part of a T cell thera…

Source https://www.fightaging.org/archives/2024/06/an-artificial-lymph-node-to-guide-t-cells-to-attack-specific-targets-such-as-cancers/

Lymph nodes are points of coordination for the immune system, where T cells of the adaptive immune system are presented with antibodies that match target molecules, in effect given instructions as to what to attack next. Calling a structure made of biomaterials and decorated with antibodies an “artificial lymph node” does get the point across, but this is a far cry from, say, a lymph node organoid that shares a similar structure and set of cell populations with a natural lymph node. Still, the artificial structure does serve this one purpose, to instruct T cells. Researchers here envisage implanting a lymph node substitute as a part of a T cell thera…

Foamy Urine and What It Could Mean for Your Health

Source https://greatist.com/health/foamy-urine

Foamy urine can result from simple factors like a fast urine stream or more complex causes like kidney disease and diabetes.

Ever seen your pee fizz like a shaken soda and thought your toilet was pranking you? Don’t panic! Here’s everything you need to know about foamy urine, including common causes and treatments.

foamy urine

What causes foamy urine?

Seeing foam in your pee may catch you off guard. However, it doesn’t necessarily signal that a serious health issue is brewing. It could be due to something benign, like a rapid…

Source https://greatist.com/health/foamy-urine

Foamy urine can result from simple factors like a fast urine stream or more complex causes like kidney disease and diabetes.

Ever seen your pee fizz like a shaken soda and thought your toilet was pranking you? Don’t panic! Here’s everything you need to know about foamy urine, including common causes and treatments.

foamy urine

What causes foamy urine?

Seeing foam in your pee may catch you off guard. However, it doesn’t necessarily signal that a serious health issue is brewing. It could be due to something benign, like a rapid…

A Tool to Help You Love Yourself Unconditionally

Source https://tinybuddha.com/blog/a-tool-to-help-you-love-yourself-unconditionally/

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Hi friends! Today, I’m thrilled to share with you a beautiful, healing, and inspiring card deck that I’ve been obsessed with as of late.

Created by Tiny Buddha contributor Rita Loyd, the Unconditional Self-Love Message Card Deck contains fifty colorful art images, each with an accompanying message on how to cultivate unconditional self-love on the back.

At 2.5”x 3.5“, the deck is small enough to carry within a purse …

Source https://tinybuddha.com/blog/a-tool-to-help-you-love-yourself-unconditionally/

#container #sidebar,
#container aside {
display: none;
}

Hi friends! Today, I’m thrilled to share with you a beautiful, healing, and inspiring card deck that I’ve been obsessed with as of late.

Created by Tiny Buddha contributor Rita Loyd, the Unconditional Self-Love Message Card Deck contains fifty colorful art images, each with an accompanying message on how to cultivate unconditional self-love on the back.

At 2.5”x 3.5“, the deck is small enough to carry within a purse …

Reversible Cryopreservation Continues to be the Point of Focus to Expand Cryonics

Source https://www.fightaging.org/archives/2024/06/reversible-cryopreservation-continues-to-be-the-point-of-focus-to-expand-cryonics/

The cryonics industry has remained non-profit and small for fifty years. Only a few hundred people have been cryopreserved on death, a tragedy that receives to little attention. A cryopreserved individual has, in principle, some unknown odds of a restored life at some point in a more technologically capable future. Higher odds than the present end of life alternatives, of course. This is provided that the fine structure of the brain is sufficiently preserved, and there remains debate over the degree to which this can be achieved using the technologies and protocols of today. Cryonics organizations and researchers lack the resources needed to conduct the sort of research and development needed to firmly answer questions of this nature, and to effectively react to the answers by developing new approaches.
</p…

Source https://www.fightaging.org/archives/2024/06/reversible-cryopreservation-continues-to-be-the-point-of-focus-to-expand-cryonics/

The cryonics industry has remained non-profit and small for fifty years. Only a few hundred people have been cryopreserved on death, a tragedy that receives to little attention. A cryopreserved individual has, in principle, some unknown odds of a restored life at some point in a more technologically capable future. Higher odds than the present end of life alternatives, of course. This is provided that the fine structure of the brain is sufficiently preserved, and there remains debate over the degree to which this can be achieved using the technologies and protocols of today. Cryonics organizations and researchers lack the resources needed to conduct the sort of research and development needed to firmly answer questions of this nature, and to effectively react to the answers by developing new approaches.
</p…

Get Good at Finishing Things

Source https://zenhabits.net/finishing/

By Leo Babauta

Recently I had a reader write in to me about not being good at finishing things.

A few examples of things they haven’t finished:

  • They bought a course and never finished it
  • They can’t seem to stick to a diet
  • They’ve only gone on half of the hikes they want to go on in their area

I can relate! It can be hard to finish things — we get excited about something at the start, but when we get busy or things get hard or boring, our commitment wavers.

So how do we get better at finishing things? We have to deepen into commitment, and get support.

Before we get into the details, it’s important to note: commitment is a practice. It’s not something you either have or don’t have, or that you’ll always suck at. You have to practice, develop trust in yourself, learn what works, learn to bring in what’s needed for what you’re …

Source https://zenhabits.net/finishing/

By Leo Babauta

Recently I had a reader write in to me about not being good at finishing things.

A few examples of things they haven’t finished:

  • They bought a course and never finished it
  • They can’t seem to stick to a diet
  • They’ve only gone on half of the hikes they want to go on in their area

I can relate! It can be hard to finish things — we get excited about something at the start, but when we get busy or things get hard or boring, our commitment wavers.

So how do we get better at finishing things? We have to deepen into commitment, and get support.

Before we get into the details, it’s important to note: commitment is a practice. It’s not something you either have or don’t have, or that you’ll always suck at. You have to practice, develop trust in yourself, learn what works, learn to bring in what’s needed for what you’re …

I Got the Power! Your Guide to Strength Tattoos

Source https://greatist.com/discover/strength-tattoos

Think tattoos are just skin deep? Think again. Meaningful tattoos can embody strength and offer empowerment.

Permanent body art has moved from the back alleys into the mainstream, bringing with it a whole new world of reasons why peeps choose to get inked. Gone are the days when tattoo styles were just anchors, skulls, or hearts declaring “Mom.” Now, they’re as meaningful as they are beautiful, acting as marks of personal history, pains, and triumphs. 

Whether it’s a butterfly’s whisper or a dragon’s roar, each tattoo carries a weight far beyond its visual appeal. If you’re thinking of getting inked with a symbol of inner strength, continue reading to learn more about tattoo designs that adorn your body and serve as powerful reminders of who you are and all you’ve overcome.

<img loading="lazy" width="1297" height="729" src=…

Source https://greatist.com/discover/strength-tattoos

Think tattoos are just skin deep? Think again. Meaningful tattoos can embody strength and offer empowerment.

Permanent body art has moved from the back alleys into the mainstream, bringing with it a whole new world of reasons why peeps choose to get inked. Gone are the days when tattoo styles were just anchors, skulls, or hearts declaring “Mom.” Now, they’re as meaningful as they are beautiful, acting as marks of personal history, pains, and triumphs. 

Whether it’s a butterfly’s whisper or a dragon’s roar, each tattoo carries a weight far beyond its visual appeal. If you’re thinking of getting inked with a symbol of inner strength, continue reading to learn more about tattoo designs that adorn your body and serve as powerful reminders of who you are and all you’ve overcome.

<img loading="lazy" width="1297" height="729" src=…

Embracing Rejection Helped Me Love Dating and Meet My Husband

Source https://tinybuddha.com/blog/embracing-rejection-helped-me-love-dating-and-meet-my-husband/

“Every time I thought I was being rejected from something good, I was actually being redirected to something better.” ~Steve Maraboli

I think most single people these days dream of meeting someone “in real life.”

The fantasy is that in “the real world” it’ll be easier.

I dated BA and AA. Before apps and after apps.

The sad truth is that technology changed the game whether you’re on apps or not.

The life skill of walking up to someone in a bar and starting a conversation out of thin air has vanished. The ability to be the receiver of that conversation without the safety net of a screen followed clo…

Source https://tinybuddha.com/blog/embracing-rejection-helped-me-love-dating-and-meet-my-husband/

“Every time I thought I was being rejected from something good, I was actually being redirected to something better.” ~Steve Maraboli

I think most single people these days dream of meeting someone “in real life.”

The fantasy is that in “the real world” it’ll be easier.

I dated BA and AA. Before apps and after apps.

The sad truth is that technology changed the game whether you’re on apps or not.

The life skill of walking up to someone in a bar and starting a conversation out of thin air has vanished. The ability to be the receiver of that conversation without the safety net of a screen followed clo…

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