In Search of Immune System Differences in Long-Lived Mammals

Source https://www.fightaging.org/archives/2023/09/in-search-of-immune-system-differences-in-long-lived-mammals/

What are the mechanisms that allow long-lived mammals to be long-lived? It remains to be seen as to whether it will be cost-effective and of sizable benefit to isolate specific genetic differences that can be used as a basis for therapies in humans, but it isn’t a terrible idea to conduct the search. Clearly cancer suppression is an interesting topic, and one it might well be possible to build novel therapies based on the study of whales and elephants. Another good place to start is the operation of the immune system. The age-related decline of immune function is clearly important to the onset and progression of age-related disease. We might well ask how long-lived mammals maintain functional immune systems …

Source https://www.fightaging.org/archives/2023/09/in-search-of-immune-system-differences-in-long-lived-mammals/

What are the mechanisms that allow long-lived mammals to be long-lived? It remains to be seen as to whether it will be cost-effective and of sizable benefit to isolate specific genetic differences that can be used as a basis for therapies in humans, but it isn’t a terrible idea to conduct the search. Clearly cancer suppression is an interesting topic, and one it might well be possible to build novel therapies based on the study of whales and elephants. Another good place to start is the operation of the immune system. The age-related decline of immune function is clearly important to the onset and progression of age-related disease. We might well ask how long-lived mammals maintain functional immune systems …

Podcast 410 | Declutter Slowly

Source https://www.theminimalists.com/p410/

In this public episode of The Minimalists Podcast, we talk about clutter as an anxiety crutch and letting go of coupons. Watch all 2 hours of episode 410 on The Minimalists Private Podcast.

Subscribe

Apple · Spotify · Google · Soundcloud · MP3

Discussed in This Episode

  • Can clutter be an anxiety crutch?
  • How c…

Source https://www.theminimalists.com/p410/

In this public episode of The Minimalists Podcast, we talk about clutter as an anxiety crutch and letting go of coupons. Watch all 2 hours of episode 410 on The Minimalists Private Podcast.

Subscribe

Apple · Spotify · Google · Soundcloud · MP3

Discussed in This Episode

  • Can clutter be an anxiety crutch?
  • How c…

Leaking Gut, Leaking Blood Vessels, Leaking Blood Brain Barrier

Source https://www.fightaging.org/archives/2023/09/leaking-gut-leaking-blood-vessels-leaking-blood-brain-barrier/

In today’s open access paper, researchers attempt to throw a big tent over three distinct issues in the aging of the body and brain. Firstly, the intestinal barrier fails, allowing bacteria and bacterial metabolites into tissue and the circulation, where they can provoke dysfunction and inflammation. Secondly, blood vessels become leaky, harming surrounding tissues by allowing excessive fluid, inappropriate molecules and cells to escape. Lastly, the blood-brain barrier leaks; this is a more specialized barrier layer surrounding blood vessels in the brain, and when it leaks, the passage of unwanted cells and molecules into the brain again produces dysfunction and inflammation.

Can one really draw a circle around these three q…

Source https://www.fightaging.org/archives/2023/09/leaking-gut-leaking-blood-vessels-leaking-blood-brain-barrier/

In today’s open access paper, researchers attempt to throw a big tent over three distinct issues in the aging of the body and brain. Firstly, the intestinal barrier fails, allowing bacteria and bacterial metabolites into tissue and the circulation, where they can provoke dysfunction and inflammation. Secondly, blood vessels become leaky, harming surrounding tissues by allowing excessive fluid, inappropriate molecules and cells to escape. Lastly, the blood-brain barrier leaks; this is a more specialized barrier layer surrounding blood vessels in the brain, and when it leaks, the passage of unwanted cells and molecules into the brain again produces dysfunction and inflammation.

Can one really draw a circle around these three q…

How I Stopped Feeling Like There Was Something Wrong with Me

Source https://tinybuddha.com/blog/how-i-stopped-feeling-like-there-was-something-wrong-with-me/

“A flower does not think of competing with the flower next to it. It just blooms.” – Zen Shin

In the past, I often felt like I didn’t belong in groups of women.

Sometimes I felt like something was wrong with me, like I was othered in one way or another: too sporty, too quiet, too serious, too emotional, too dumb, too smart, too wild, too normal, too sexual, too prude.

Other times, I felt like something was wrong with all of them. Girls’ nights and bachelorette parties? The screeching voices, the loud laughs, the mundane conversations about makeup, skin care routines, and lip injecti…

Source https://tinybuddha.com/blog/how-i-stopped-feeling-like-there-was-something-wrong-with-me/

“A flower does not think of competing with the flower next to it. It just blooms.” – Zen Shin

In the past, I often felt like I didn’t belong in groups of women.

Sometimes I felt like something was wrong with me, like I was othered in one way or another: too sporty, too quiet, too serious, too emotional, too dumb, too smart, too wild, too normal, too sexual, too prude.

Other times, I felt like something was wrong with all of them. Girls’ nights and bachelorette parties? The screeching voices, the loud laughs, the mundane conversations about makeup, skin care routines, and lip injecti…

Ask Joan: I Don’t Want to Move in With Him!

Source https://seniorplanet.org/articles-joan-not-living-together/

A reader asks Joan how to tell her long-time lover she doesn’t want to move in with him.  Is LAT the answer?

The post Ask Joan: I Don’t Want to Move in With Him! appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-joan-not-living-together/

A reader asks Joan how to tell her long-time lover she doesn’t want to move in with him.  Is LAT the answer?

The post Ask Joan: I Don’t Want to Move in With Him! appeared first on Senior Planet from AARP.

Open Thread: The Unwritten Rules of Aging

Source https://seniorplanet.org/articles-open-thread-unwritten-rules/

A dinner with friends made me discover I was encouraging a stereotype – and my first Unwritten Rule about Aging was born. What’s yours?

The post Open Thread: The Unwritten Rules of Aging appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-open-thread-unwritten-rules/

A dinner with friends made me discover I was encouraging a stereotype – and my first Unwritten Rule about Aging was born. What’s yours?

The post Open Thread: The Unwritten Rules of Aging appeared first on Senior Planet from AARP.

How I Found a Beautiful Purpose by Giving Up the Search

Source https://tinybuddha.com/blog/how-i-found-a-beautiful-purpose-by-giving-up-the-search/

“You and your purpose in life are the same thing. Your purpose is to be you.” ~George Alexiou

We all play a pivotal role in society. But I’ve toyed with the New Age spiritual notion that we all have a unique purpose on Earth to fulfill—a purpose for which we have chosen to be here.

I used to wonder if I could only be happy if I found this one resounding and elusive purpose.

If I knew my soul’s purpose, I believed my life would suddenly have endless meaning and vitality. Once I found my purpose, I would leap out of bed every morning and dance around the kitchen, singing as I made my morning coffee. Because my soul had…

Source https://tinybuddha.com/blog/how-i-found-a-beautiful-purpose-by-giving-up-the-search/

“You and your purpose in life are the same thing. Your purpose is to be you.” ~George Alexiou

We all play a pivotal role in society. But I’ve toyed with the New Age spiritual notion that we all have a unique purpose on Earth to fulfill—a purpose for which we have chosen to be here.

I used to wonder if I could only be happy if I found this one resounding and elusive purpose.

If I knew my soul’s purpose, I believed my life would suddenly have endless meaning and vitality. Once I found my purpose, I would leap out of bed every morning and dance around the kitchen, singing as I made my morning coffee. Because my soul had…

Fight Aging! Newsletter, September 18th 2023

Source https://www.fightaging.org/archives/2023/09/fight-aging-newsletter-september-18th-2023/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/


Contents

Source https://www.fightaging.org/archives/2023/09/fight-aging-newsletter-september-18th-2023/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/


Contents

Navigating Social Anxiety: 10 Powerful NLP Tools for Personal Growth

Source https://tinybuddha.com/blog/navigating-social-anxiety-10-powerful-nlp-tools-for-personal-growth/

“We need each other, deeper than anyone ever dares to admit even to themselves. I think it is a genetic imperative that we huddle together and hold on to each other.” ~Patch Adams

A few years ago, I was invited to a work event. When I received the invitation a few months before, the idea seemed fun—a friendly gathering with colleagues, filled with vibrant conversations and laughter, enabling me to create human connections in the workplace.

As the day approached, a familiar knot tightened in my stomach, I couldn’t breathe deeply, and an overwhelming sense of unease took hold. I was caught in the hand of social anxiety.

Close to the event, the mere thought of attending sent my mind spiralling into millions of anxious thoughts and self-doubt. The fear o…

Source https://tinybuddha.com/blog/navigating-social-anxiety-10-powerful-nlp-tools-for-personal-growth/

“We need each other, deeper than anyone ever dares to admit even to themselves. I think it is a genetic imperative that we huddle together and hold on to each other.” ~Patch Adams

A few years ago, I was invited to a work event. When I received the invitation a few months before, the idea seemed fun—a friendly gathering with colleagues, filled with vibrant conversations and laughter, enabling me to create human connections in the workplace.

As the day approached, a familiar knot tightened in my stomach, I couldn’t breathe deeply, and an overwhelming sense of unease took hold. I was caught in the hand of social anxiety.

Close to the event, the mere thought of attending sent my mind spiralling into millions of anxious thoughts and self-doubt. The fear o…

Ask The Techspert: Your Guide to Senior Planet Resources

Source https://seniorplanet.org/article-techspert-senior-planet-resources/

Are you familiar with all of Senior Planet’s Tech resources for older adults? This article covers most of them and their links.

The post Ask The Techspert: Your Guide to Senior Planet Resources appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/article-techspert-senior-planet-resources/

Are you familiar with all of Senior Planet’s Tech resources for older adults? This article covers most of them and their links.

The post Ask The Techspert: Your Guide to Senior Planet Resources appeared first on Senior Planet from AARP.

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