Urolithin A as a Senomorphic Treatment

Source https://www.fightaging.org/archives/2025/10/urolithin-a-as-a-senomorphic-treatment/

Urolithin A is a metabolite produced by gut bacteria, widely used as a dietary supplement, and has attracted attention from the aging research community for its positive effects on mitochondrial function. Of the various approaches to improving mitochondrial function with compounds classed as supplements, urolithin A is arguably the one that researchers know the least about when it comes to how exactly it functions, but equally there is stiff competition here. Knowledge of the exact mechanisms involved in translating the known immediate biochemical interactions of various compounds to better functioning mitochondria is sketchy at best for <a href="https://www.fightaging.org/archives/2018/07/more-than-you-wanted-to-know-about-nad-in-metabolism-and-aging…

Source https://www.fightaging.org/archives/2025/10/urolithin-a-as-a-senomorphic-treatment/

Urolithin A is a metabolite produced by gut bacteria, widely used as a dietary supplement, and has attracted attention from the aging research community for its positive effects on mitochondrial function. Of the various approaches to improving mitochondrial function with compounds classed as supplements, urolithin A is arguably the one that researchers know the least about when it comes to how exactly it functions, but equally there is stiff competition here. Knowledge of the exact mechanisms involved in translating the known immediate biochemical interactions of various compounds to better functioning mitochondria is sketchy at best for <a href="https://www.fightaging.org/archives/2018/07/more-than-you-wanted-to-know-about-nad-in-metabolism-and-aging…

Targeting STING to Reduce Neuroinflammation

Source https://www.fightaging.org/archives/2025/10/targeting-sting-to-reduce-neuroinflammation/

Cells evolved to detect foreign DNA and respond with inflammatory signaling. Unfortunately aging brings with it the mislocalization of fragments of the cell’s own DNA that is then misidentified as foreign, triggering these same inflammatory pathways. This response, and a number of other responses to forms of damage inside the cell, converge on the regulatory protein STING. The activity of STING that leads to inflammation is thus an interesting target for the treatment of age-related conditions involving excessive chronic inflammation. As for near all of the present potential approaches to the chronic inflammation of aging, sabotaging STING will harm the normal <a…

Source https://www.fightaging.org/archives/2025/10/targeting-sting-to-reduce-neuroinflammation/

Cells evolved to detect foreign DNA and respond with inflammatory signaling. Unfortunately aging brings with it the mislocalization of fragments of the cell’s own DNA that is then misidentified as foreign, triggering these same inflammatory pathways. This response, and a number of other responses to forms of damage inside the cell, converge on the regulatory protein STING. The activity of STING that leads to inflammation is thus an interesting target for the treatment of age-related conditions involving excessive chronic inflammation. As for near all of the present potential approaches to the chronic inflammation of aging, sabotaging STING will harm the normal <a…

Engineering Greater Export of Amyloid-β through the Blood-Brain Barrier

Source https://www.fightaging.org/archives/2025/10/engineering-greater-export-of-amyloid-%CE%B2-through-the-blood-brain-barrier/

Amyloid-β is an anti-microbial peptide, a component of the innate immune system. In the brain it is best known for increasing with age, misfolding, and then aggregating into toxic deposits. The presence of these aggregrates is thought to be the initial cause of Alzheimer’s disease, eventually inducing the late stage mechanisms of neuroinflammation and tau aggregation that kill neurons and ultimately kill the patient. On its own, it seems likely that amyloid-β aggregation is capable of producing on…

Source https://www.fightaging.org/archives/2025/10/engineering-greater-export-of-amyloid-%CE%B2-through-the-blood-brain-barrier/

Amyloid-β is an anti-microbial peptide, a component of the innate immune system. In the brain it is best known for increasing with age, misfolding, and then aggregating into toxic deposits. The presence of these aggregrates is thought to be the initial cause of Alzheimer’s disease, eventually inducing the late stage mechanisms of neuroinflammation and tau aggregation that kill neurons and ultimately kill the patient. On its own, it seems likely that amyloid-β aggregation is capable of producing on…

How to Be Well in Unwell Times

Source https://tinybuddha.com/blog/how-to-be-well-in-unwell-times/

If you wake up anxious these days, you’re not alone. Between the news cycle, global uncertainty, and the chaos of daily life, it can feel like the world is spinning faster than we can catch our breath.

I’ve been feeling more anxious than usual myself lately—partly because of everything happening in my own life, and partly because so much in the world feels beyond our control. And yet, even in times like these, it’s still possible to find a sense of calm—to create a small pocket of peace within yourself that isn’t so easily shaken by what’s happening outside.

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Source https://tinybuddha.com/blog/how-to-be-well-in-unwell-times/

If you wake up anxious these days, you’re not alone. Between the news cycle, global uncertainty, and the chaos of daily life, it can feel like the world is spinning faster than we can catch our breath.

I’ve been feeling more anxious than usual myself lately—partly because of everything happening in my own life, and partly because so much in the world feels beyond our control. And yet, even in times like these, it’s still possible to find a sense of calm—to create a small pocket of peace within yourself that isn’t so easily shaken by what’s happening outside.

<p data-start="267…

Targeting Senescent Cells in the Treatment of Cancer

Source https://www.fightaging.org/archives/2025/10/targeting-senescent-cells-in-the-treatment-of-cancer/

It seems clear that it is a good idea to remove the excess senescent cells generated by a cancer therapy after the cancer is defeated, or at the very least permanently suppress the inflammatory signaling generated by those senescent cells. The added burden of cellular senescence carried by cancer survivors is likely a major contribution to a shorter life expectancy and raised risk of age-related disease. Whether it is a good idea to remove or alter the behavior of senescent cells during cancer therapy, while a cancer is still active, remains a debated topic. The answer may be different on a cancer by cancer basis. The presence of senescent cells can both harm and help the growth of cancerous cells, but which effects dominate in any given context may be hard to determine in advance, depending on the biochemistry …

Source https://www.fightaging.org/archives/2025/10/targeting-senescent-cells-in-the-treatment-of-cancer/

It seems clear that it is a good idea to remove the excess senescent cells generated by a cancer therapy after the cancer is defeated, or at the very least permanently suppress the inflammatory signaling generated by those senescent cells. The added burden of cellular senescence carried by cancer survivors is likely a major contribution to a shorter life expectancy and raised risk of age-related disease. Whether it is a good idea to remove or alter the behavior of senescent cells during cancer therapy, while a cancer is still active, remains a debated topic. The answer may be different on a cancer by cancer basis. The presence of senescent cells can both harm and help the growth of cancerous cells, but which effects dominate in any given context may be hard to determine in advance, depending on the biochemistry …

Tech Hub: Save Money on Last Year’s Phone Models

Source https://seniorplanet.org/articles-tech-hub-save-on-phones/

The Tech Hub helps Senior Planet readers learn what to look for, and how to save, when shopping for a phone (just in time for the holiday buying season!)

The post Tech Hub: Save Money on Last Year’s Phone Models appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-tech-hub-save-on-phones/

The Tech Hub helps Senior Planet readers learn what to look for, and how to save, when shopping for a phone (just in time for the holiday buying season!)

The post Tech Hub: Save Money on Last Year’s Phone Models appeared first on Senior Planet from AARP.

The Role of Cellular Senescence in Cardiovascular Disease

Source https://www.fightaging.org/archives/2025/10/the-role-of-cellular-senescence-in-cardiovascular-disease/

When a cell becomes senescent it ceases replication, expands in size, and secretes a mix of pro-growth, pro-inflammatory molecules known as the senescence-associated secretory phenotype (SASP). Cells become senescent throughout life, mostly upon reaching the Hayflick limit on replication. Forms of damage, particularly DNA damage that might lead to cancer, the signaling of other senescent cells, and a toxic environment can …

Source https://www.fightaging.org/archives/2025/10/the-role-of-cellular-senescence-in-cardiovascular-disease/

When a cell becomes senescent it ceases replication, expands in size, and secretes a mix of pro-growth, pro-inflammatory molecules known as the senescence-associated secretory phenotype (SASP). Cells become senescent throughout life, mostly upon reaching the Hayflick limit on replication. Forms of damage, particularly DNA damage that might lead to cancer, the signaling of other senescent cells, and a toxic environment can …

The Enormous Cost of Being the One Who Holds Everything Together

Source https://tinybuddha.com/blog/the-enormous-cost-of-being-the-one-who-holds-everything-together/

“For most of history, Anonymous was a woman.” ~Virginia Woolf

There’s a kind of work in our society that doesn’t come with a title or pay, and for a long time, I didn’t even notice I was doing it. I just lived inside it. It shaped my days, my stress, my identity.

These days, I see it more clearly. I can name it now. I don’t only live inside it, but I still return to it—especially as a parent, especially when things stretch thin. The difference is now, I pause. I reflect. I ask myself if I have to hold it all. Sometimes I still do. But not by default. Not blindly. Well, usually anyway.

I’m writing to make the invisible visible. To name what I rarely h…

Source https://tinybuddha.com/blog/the-enormous-cost-of-being-the-one-who-holds-everything-together/

“For most of history, Anonymous was a woman.” ~Virginia Woolf

There’s a kind of work in our society that doesn’t come with a title or pay, and for a long time, I didn’t even notice I was doing it. I just lived inside it. It shaped my days, my stress, my identity.

These days, I see it more clearly. I can name it now. I don’t only live inside it, but I still return to it—especially as a parent, especially when things stretch thin. The difference is now, I pause. I reflect. I ask myself if I have to hold it all. Sometimes I still do. But not by default. Not blindly. Well, usually anyway.

I’m writing to make the invisible visible. To name what I rarely h…

Metabolomic Signatures of Extreme Old Age

Source https://www.fightaging.org/archives/2025/10/metabolomic-signatures-of-extreme-old-age/

It remains an open question as to whether studying the biochemistry of extremely old people can provide a basis for interventions that will help everyone live meaningfully longer. If genetics has little influence on longevity for the vast majority of people, as seems to be the case, then differences observed in extremely old people emerge from (a) lifestyle choices that we can control and (b) exposures that we presently have less control over, such as infectious disease burden and composition of the gut microbiome. However, any of the biochemical differences …

Source https://www.fightaging.org/archives/2025/10/metabolomic-signatures-of-extreme-old-age/

It remains an open question as to whether studying the biochemistry of extremely old people can provide a basis for interventions that will help everyone live meaningfully longer. If genetics has little influence on longevity for the vast majority of people, as seems to be the case, then differences observed in extremely old people emerge from (a) lifestyle choices that we can control and (b) exposures that we presently have less control over, such as infectious disease burden and composition of the gut microbiome. However, any of the biochemical differences …

5 Things You Should Never Feel Guilty About Getting Rid Of

Source https://www.theminimalists.com/guilt/

The Minimalists discuss decluttering without guilt.

What’s one item you felt guilty about getting rid of? Let us know in the YouTube comments.

The post 5 Things You Should Never Feel Guilty About Getting Rid Of appeared first on The Minimalists.

Source https://www.theminimalists.com/guilt/

The Minimalists discuss decluttering without guilt.

What’s one item you felt guilty about getting rid of? Let us know in the YouTube comments.

The post 5 Things You Should Never Feel Guilty About Getting Rid Of appeared first on The Minimalists.

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