Source https://www.fightaging.org/archives/2024/05/improved-autophagy-slows-age-related-muscle-loss-in-mice/
Improved autophagy is implicated in many of the approaches shown to slow aging in animal models. An open question is whether more targeted approaches to altering the regulation of autophagy in aged cells can improve matters to a greater degree than, for example, exercise or the practice of calorie restriction, both of which are known to produce general improvements in autophagy. Researchers here show that improvement of autophagy via increased expression of TRP53INP2 in old mice can reduce the age-related loss muscle mass and function that leads to sarcopenia. It seems an interesting target for further development of t…
Source https://www.fightaging.org/archives/2024/05/improved-autophagy-slows-age-related-muscle-loss-in-mice/
Improved autophagy is implicated in many of the approaches shown to slow aging in animal models. An open question is whether more targeted approaches to altering the regulation of autophagy in aged cells can improve matters to a greater degree than, for example, exercise or the practice of calorie restriction, both of which are known to produce general improvements in autophagy. Researchers here show that improvement of autophagy via increased expression of TRP53INP2 in old mice can reduce the age-related loss muscle mass and function that leads to sarcopenia. It seems an interesting target for further development of t…
Source https://tinybuddha.com/blog/what-forgiveness-really-means-and-why-its-the-ultimate-freedom/
I used to loathe the word “forgiveness.”
What it meant to me was that someone could hurt me, lie to me, or even abuse me, say “sorry,” and I was supposed to pretend like nothing happened. If I didn’t, they would say to me, “I thought you were a forgiving person,” or “What? I already said I was sorry.”
It felt awful, outside and inside.
I had one relationship that I knew very well wasn’t good for me and I wanted out of, but my misunderstanding of what the word “forgiveness” meant kept me stuck there for a very long time.
The person would lie repeatedly and never come clean. When th…
Source https://tinybuddha.com/blog/what-forgiveness-really-means-and-why-its-the-ultimate-freedom/
I used to loathe the word “forgiveness.”
What it meant to me was that someone could hurt me, lie to me, or even abuse me, say “sorry,” and I was supposed to pretend like nothing happened. If I didn’t, they would say to me, “I thought you were a forgiving person,” or “What? I already said I was sorry.”
It felt awful, outside and inside.
I had one relationship that I knew very well wasn’t good for me and I wanted out of, but my misunderstanding of what the word “forgiveness” meant kept me stuck there for a very long time.
The person would lie repeatedly and never come clean. When th…
Source https://www.fightaging.org/archives/2024/05/excess-intracellular-cholesterol-provokes-macrophage-senescence/
One the important themes of the research and development at Repair Biotechnologies is that localized excesses of cholesterol arise with age, leading to excess intracellular cholesterol, which is a pathological mechanism that disrupts cell behavior and kills cells. Getting rid of these localized excesses of cholesterol is challenging, however, unless resorting to some form of engineered protein machinery or gene therapy. Cells cannot break down cholesterol and there is no good way to bind enough of the excess cholesterol to some form of small molecule for sequestration and disposal without also targeting vital cholesterol in cell membranes and elsewhere. As this paper notes, excess cholesterol is clearly a meaningful problem in aging.
<p…
Source https://www.fightaging.org/archives/2024/05/excess-intracellular-cholesterol-provokes-macrophage-senescence/
One the important themes of the research and development at Repair Biotechnologies is that localized excesses of cholesterol arise with age, leading to excess intracellular cholesterol, which is a pathological mechanism that disrupts cell behavior and kills cells. Getting rid of these localized excesses of cholesterol is challenging, however, unless resorting to some form of engineered protein machinery or gene therapy. Cells cannot break down cholesterol and there is no good way to bind enough of the excess cholesterol to some form of small molecule for sequestration and disposal without also targeting vital cholesterol in cell membranes and elsewhere. As this paper notes, excess cholesterol is clearly a meaningful problem in aging.
<p…
Source https://www.fightaging.org/archives/2024/05/the-future-of-vaccination-in-the-old-must-involve-reversal-of-immunosenescence/
Robust modern forms of vaccination that were developed in the 20th century remain one of the most important forms of medical technology. Infectious diseases are not going away any time soon, and continue to cause a sizable fraction of human mortality, even though that fraction is much reduced in our era. Unfortunately, effective vaccination depends on an effective immune system, and thus vaccines tend to perform increasingly poorly with advancing age. As we age our immune system becomes ever less capable, a decline into immunosenescence caused by a range of contributing processes: involution…
Source https://www.fightaging.org/archives/2024/05/the-future-of-vaccination-in-the-old-must-involve-reversal-of-immunosenescence/
Robust modern forms of vaccination that were developed in the 20th century remain one of the most important forms of medical technology. Infectious diseases are not going away any time soon, and continue to cause a sizable fraction of human mortality, even though that fraction is much reduced in our era. Unfortunately, effective vaccination depends on an effective immune system, and thus vaccines tend to perform increasingly poorly with advancing age. As we age our immune system becomes ever less capable, a decline into immunosenescence caused by a range of contributing processes: involution…
Source https://www.fightaging.org/archives/2024/05/stair-climbing-as-an-example-of-physical-activity-correlated-with-reduced-mortality-risk/
While researchers here focus specifically on stair climbing as a form of physical activity to compare against risk of mortality in later life, there are any number of other studies that focus on activity more generally, or on other forms of moderate to vigorous exercise. The consensus across epidemiological studies is that physical activity correlates with reduced mortality. Animal studies have been used to demonstrate that the exercise in fact causes that reduced mortality, and it is reasonable to consider that the same is true in humans.
Cardiovascular disease is largely preventable through actions like exercise. However, more than one in four adults worldwide do not meet recommended levels of physical activity. Stair climbing is a practical and easily accessible form of physical activity which is often overlooked. This study investigated whether climbing stairs, as a form of physic…
Source https://www.fightaging.org/archives/2024/05/stair-climbing-as-an-example-of-physical-activity-correlated-with-reduced-mortality-risk/
While researchers here focus specifically on stair climbing as a form of physical activity to compare against risk of mortality in later life, there are any number of other studies that focus on activity more generally, or on other forms of moderate to vigorous exercise. The consensus across epidemiological studies is that physical activity correlates with reduced mortality. Animal studies have been used to demonstrate that the exercise in fact causes that reduced mortality, and it is reasonable to consider that the same is true in humans.
Cardiovascular disease is largely preventable through actions like exercise. However, more than one in four adults worldwide do not meet recommended levels of physical activity. Stair climbing is a practical and easily accessible form of physical activity which is often overlooked. This study investigated whether climbing stairs, as a form of physic…
Source https://www.fightaging.org/archives/2024/05/progress-towards-cardiomyocyte-cell-therapy-for-the-injured-heart/
Researchers here demonstrate an approach to cell therapy for an injured heart that produces lesser degrees of abnormal function than prior efforts. There has been some concern that delivering new cells to the heart to spur greater regeneration will disrupt the electrical regulation of heartbeats, as animal studies suggested an unacceptable risk of arrhythmia following treatment. This work still makes use of cardiomyocytes generated from induced pluripotent stem cells, already accomplished by a number of other groups, but differences in the details of the approach appear to make a positive change in the outcome.
In a recent study, a research team tested a new str…
Source https://www.fightaging.org/archives/2024/05/progress-towards-cardiomyocyte-cell-therapy-for-the-injured-heart/
Researchers here demonstrate an approach to cell therapy for an injured heart that produces lesser degrees of abnormal function than prior efforts. There has been some concern that delivering new cells to the heart to spur greater regeneration will disrupt the electrical regulation of heartbeats, as animal studies suggested an unacceptable risk of arrhythmia following treatment. This work still makes use of cardiomyocytes generated from induced pluripotent stem cells, already accomplished by a number of other groups, but differences in the details of the approach appear to make a positive change in the outcome.
In a recent study, a research team tested a new str…
Source https://www.fightaging.org/archives/2024/05/juventology-as-an-complementary-alternative-to-gerontology/
There are many different ways to conceptualize programs of research and development aimed at the treatment of aging. The Strategies for Engineered Negligible Senescence (SENS) is focused on aging as damage accumulation, and treatment is thus damage repair: remove senescent cells, restore mitochondrial function, clear out harmful protein aggregates, and so forth. Programmed aging viewpoints instead focus on ways to alter what are suspected to be evolved programs that drive aging, with this line of thought most often centered around the reversal of epigenetic…
Source https://www.fightaging.org/archives/2024/05/juventology-as-an-complementary-alternative-to-gerontology/
There are many different ways to conceptualize programs of research and development aimed at the treatment of aging. The Strategies for Engineered Negligible Senescence (SENS) is focused on aging as damage accumulation, and treatment is thus damage repair: remove senescent cells, restore mitochondrial function, clear out harmful protein aggregates, and so forth. Programmed aging viewpoints instead focus on ways to alter what are suspected to be evolved programs that drive aging, with this line of thought most often centered around the reversal of epigenetic…
Source https://zenhabits.net/abundance-of-spring/
For many of us in the Northern hemisphere, Spring has fully arrived: gorgeous sunshine, warmer weather, green trees, blossoms. It’s glorious!
With Spring comes life springing into action, full of abundance. This is the chaos of life, full and energetic and exuberant. It’s chaotic but in the most affirming of ways.
This abundance and chaos can fill us up, if we let it. If you’re feeling drained and empty, then you can let yourself feel the nourishing abundance of life all around you. Chaos can be stressful, or restorative — depending on our attitude towards it.
Here’s the practice:
- Go outside and look at the sunlight and abundant nature all around you.
- Let yourself relax and open to this abundance, and soak it in as a way to fill up your cup.
- Imagine that seeing the abundant life and greenery can relax you, bring life…
Source https://zenhabits.net/abundance-of-spring/
For many of us in the Northern hemisphere, Spring has fully arrived: gorgeous sunshine, warmer weather, green trees, blossoms. It’s glorious!
With Spring comes life springing into action, full of abundance. This is the chaos of life, full and energetic and exuberant. It’s chaotic but in the most affirming of ways.
This abundance and chaos can fill us up, if we let it. If you’re feeling drained and empty, then you can let yourself feel the nourishing abundance of life all around you. Chaos can be stressful, or restorative — depending on our attitude towards it.
Here’s the practice:
- Go outside and look at the sunlight and abundant nature all around you.
- Let yourself relax and open to this abundance, and soak it in as a way to fill up your cup.
- Imagine that seeing the abundant life and greenery can relax you, bring life…
Source https://seniorplanet.org/articles-bone-health/
After age 60, fractures could mean hospitalization and a long recovery – so get the scoop on bone health.
The post Bone Up on Bone Health appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-bone-health/
After age 60, fractures could mean hospitalization and a long recovery – so get the scoop on bone health.
The post Bone Up on Bone Health appeared first on Senior Planet from AARP.
…
Source https://tinybuddha.com/blog/tiny-buddhas-self-care-course-buy-one-give-one-sale/
As we get older, we tend to get clearer on what matters most to us in life. For me, it’s self-care and relationships. If you share my top values, you’re in luck, because today’s special offer honors both of those things!
In my experience, self-care and relationships have been deeply intertwined—because I’ve found that deep-level self-care reinforces my worth, which enables me to attract and hold onto healthy relationships. Which then inspires me to continue taking good care of myself so I can give the best of myself to the people I love (without losing myself in the process).
This isn’t easy or instinctive for a lot of us. Many of us were wired young to disre…
Source https://tinybuddha.com/blog/tiny-buddhas-self-care-course-buy-one-give-one-sale/
As we get older, we tend to get clearer on what matters most to us in life. For me, it’s self-care and relationships. If you share my top values, you’re in luck, because today’s special offer honors both of those things!
In my experience, self-care and relationships have been deeply intertwined—because I’ve found that deep-level self-care reinforces my worth, which enables me to attract and hold onto healthy relationships. Which then inspires me to continue taking good care of myself so I can give the best of myself to the people I love (without losing myself in the process).
This isn’t easy or instinctive for a lot of us. Many of us were wired young to disre…