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Loss of LINE-1 Methylation in Cell Free DNA as a Biomarker of Aging

Source https://www.fightaging.org/archives/2020/12/loss-of-line-1-methylation-in-cell-free-dna-as-a-biomarker-of-aging/

In recent years, transposable element activation has come to be seen as potentially important in aging. Transposable elements such as retrotransposons are DNA sequences that can copy themselves into other locations in the genome, potentially causing all sorts of disruption. These transposable elements are repressed in youth by epigenetic mechanisms such as DNA methylation, but become more active in aging. It is unclear as to the degree that this represents a rising burden of damaged and <a href="https://en.wikiped…

Source https://www.fightaging.org/archives/2020/12/loss-of-line-1-methylation-in-cell-free-dna-as-a-biomarker-of-aging/

In recent years, transposable element activation has come to be seen as potentially important in aging. Transposable elements such as retrotransposons are DNA sequences that can copy themselves into other locations in the genome, potentially causing all sorts of disruption. These transposable elements are repressed in youth by epigenetic mechanisms such as DNA methylation, but become more active in aging. It is unclear as to the degree that this represents a rising burden of damaged and <a href="https://en.wikiped…

Healing from the Conflicting Loss of a Difficult Parent

Source http://feedproxy.google.com/~r/tinybuddha/~3/OkLGebZZ_yo/

“Deep grief sometimes is almost like a specific location, a coordinate on a map of time. When you are standing in that forest of sorrow, you cannot imagine that you could ever find your way to a better place. But if someone can assure you that they themselves have stood in that same place, and now have moved on, sometimes this will bring hope.” ~Elizabeth Gilbert, Eat, Pray, Love

I had a tumultuous and interesting relationship with my father. He was a strong, proud man in his spirit as well as in his physical appearance. In my younger years, I knew my father as the final disciplinarian, the breadwinner, and the patriarch of the family. Even at a young age, I felt disconnected from him and did not agree with his harsh parenting choices.

While I do…

Source http://feedproxy.google.com/~r/tinybuddha/~3/OkLGebZZ_yo/

“Deep grief sometimes is almost like a specific location, a coordinate on a map of time. When you are standing in that forest of sorrow, you cannot imagine that you could ever find your way to a better place. But if someone can assure you that they themselves have stood in that same place, and now have moved on, sometimes this will bring hope.” ~Elizabeth Gilbert, Eat, Pray, Love

I had a tumultuous and interesting relationship with my father. He was a strong, proud man in his spirit as well as in his physical appearance. In my younger years, I knew my father as the final disciplinarian, the breadwinner, and the patriarch of the family. Even at a young age, I felt disconnected from him and did not agree with his harsh parenting choices.

While I do…

5 Whole30 Meal Delivery Services to Help You Skip the Store in 2021

Source https://greatist.com/eat/whole30-meal-delivery

Strict, whole food diets like Whole30 are no picnic, especially when each run to Trader Joe’s requires a fresh mask and oodles of hand sanitizer.

Well, friends, it’s 2021. If subscription boxes and online shopping deliveries are bringing you *life* this year, why not combine your love of mail with your healthy eating goals?

With a Whole30-approved meal delivery service, you get nourishing noms delivered straight to your doorstep. No prep or label-reading required.

We’ve rounded up the top five meal delivery services that’ll make your Whole30 journey a whole lot easier.

<img loading="lazy" width="1296" height="728" src="https…

Source https://greatist.com/eat/whole30-meal-delivery

Strict, whole food diets like Whole30 are no picnic, especially when each run to Trader Joe’s requires a fresh mask and oodles of hand sanitizer.

Well, friends, it’s 2021. If subscription boxes and online shopping deliveries are bringing you *life* this year, why not combine your love of mail with your healthy eating goals?

With a Whole30-approved meal delivery service, you get nourishing noms delivered straight to your doorstep. No prep or label-reading required.

We’ve rounded up the top five meal delivery services that’ll make your Whole30 journey a whole lot easier.

<img loading="lazy" width="1296" height="728" src="https…

How Wet Can You Get? Here’s the DL on Vaginal Lubricants

Source https://greatist.com/health/vaginal-lubricants

Your body usually makes a natural lube when things get steamy. But sometimes hormonal changes or certain meds make things dry up. Enter, literally, vaginal lubricants.

Without enough lubrication, getting down can be pretty painful. These lubes reduce uncomfy friction during penetration (or masturbation!), keep the vag skin soft, and can increase your sexual pleasure. We’re listening 👀.

So, which lubricant will be your go-to? That depends. Here’s how to choose the best lube for a smooth ride to Pleasure Town.

Vaginal lubricants 101: Wet n’ wild benefits

While anyone can use lube, those who deal with dryness i…

Source https://greatist.com/health/vaginal-lubricants

Your body usually makes a natural lube when things get steamy. But sometimes hormonal changes or certain meds make things dry up. Enter, literally, vaginal lubricants.

Without enough lubrication, getting down can be pretty painful. These lubes reduce uncomfy friction during penetration (or masturbation!), keep the vag skin soft, and can increase your sexual pleasure. We’re listening 👀.

So, which lubricant will be your go-to? That depends. Here’s how to choose the best lube for a smooth ride to Pleasure Town.

Vaginal lubricants 101: Wet n’ wild benefits

While anyone can use lube, those who deal with dryness i…

Best Bourbon Old Fashioned Recipe (+ Video)

Source https://minimalistbaker.com/best-bourbon-old-fashioned-recipe-video/

Best Bourbon Old Fashioned Recipe (+ Video)

Man, if there’s anything to celebrate in 2020, it’s that it’s over. And what better way to celebrate than with a good cocktail?

We wanted to take a deep dive and individually test each ingredient in a classic Old Fashioned to really come up with that cocktail bar-worthy beverage. Good news: We think we’ve done it.

What is an Old Fashioned?

In simple terms, an Old Fashioned is a cocktail made of bourbon, sugar, bitters, orange, and a cherry.

<a href="https://minimalistbaker.com/best-bourbon-old-fash…

Source https://minimalistbaker.com/best-bourbon-old-fashioned-recipe-video/

Best Bourbon Old Fashioned Recipe (+ Video)

Man, if there’s anything to celebrate in 2020, it’s that it’s over. And what better way to celebrate than with a good cocktail?

We wanted to take a deep dive and individually test each ingredient in a classic Old Fashioned to really come up with that cocktail bar-worthy beverage. Good news: We think we’ve done it.

What is an Old Fashioned?

In simple terms, an Old Fashioned is a cocktail made of bourbon, sugar, bitters, orange, and a cherry.

<a href="https://minimalistbaker.com/best-bourbon-old-fash…

Fight Aging! Newsletter, December 28th 2020

Source https://www.fightaging.org/archives/2020/12/fight-aging-newsletter-december-28th-2020/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/

Contents

  • A Proof of Concept Attempt to Assess the Impact of First Generation Senolytic Drugs by Looking at Past Usage</…

Source https://www.fightaging.org/archives/2020/12/fight-aging-newsletter-december-28th-2020/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/

Contents

  • A Proof of Concept Attempt to Assess the Impact of First Generation Senolytic Drugs by Looking at Past Usage</…

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