The Gift of Being Single (More Joy, Less Fear)

Source https://tinybuddha.com/blog/the-gift-of-being-single-more-joy-less-fear/

“The greatest thing in the world is to know how to belong to oneself.” ~Michel de Montaigne

Some people fear spiders. Some fear public speaking.

My biggest fear? That my plus-one will always be my own reflection.

More and more people are finding themselves in the single life—not because they joyfully signed up for it, but because they’ve quietly resigned themselves to it. Being alone forever is one of the worst things most people can imagine. And yet, nobody’s talking about it.

I have no interest in bashing men—I love them. And I’m not here to shame relationships—I…

Source https://tinybuddha.com/blog/the-gift-of-being-single-more-joy-less-fear/

“The greatest thing in the world is to know how to belong to oneself.” ~Michel de Montaigne

Some people fear spiders. Some fear public speaking.

My biggest fear? That my plus-one will always be my own reflection.

More and more people are finding themselves in the single life—not because they joyfully signed up for it, but because they’ve quietly resigned themselves to it. Being alone forever is one of the worst things most people can imagine. And yet, nobody’s talking about it.

I have no interest in bashing men—I love them. And I’m not here to shame relationships—I…

CD57 as a Marker of Immunological Aging, but Not Immune Cell Senescence

Source https://www.fightaging.org/archives/2025/12/cd57-as-a-marker-of-immunological-aging-but-not-immune-cell-senescence/

Even in this age of single cell sequencing, a great deal of the categorization and counting of cells is still accomplished via assessment of cell surface proteins. The ability to cheaply create and manufacture novel antibodies that selectively bind to specific proteins naturally led to technologies such as flow cytometry that can separate and count cells that express a specific surface protein, or high versus low levels of that surface protein. The large number of proteins with names that start with “CD” for cluster of differentiation are so named because researchers have spent a lot of time looking for ways to distinguish different populations of <a href="https://en.wikipedia…

Source https://www.fightaging.org/archives/2025/12/cd57-as-a-marker-of-immunological-aging-but-not-immune-cell-senescence/

Even in this age of single cell sequencing, a great deal of the categorization and counting of cells is still accomplished via assessment of cell surface proteins. The ability to cheaply create and manufacture novel antibodies that selectively bind to specific proteins naturally led to technologies such as flow cytometry that can separate and count cells that express a specific surface protein, or high versus low levels of that surface protein. The large number of proteins with names that start with “CD” for cluster of differentiation are so named because researchers have spent a lot of time looking for ways to distinguish different populations of <a href="https://en.wikipedia…

Decluttering When You’re Stressed Out

Source https://www.theminimalists.com/underpressure/

The Minimalists speak with Judah Smith about minimizing under pressure.

How do you deal with stress? Let us know in the YouTube comments.

The post Decluttering When You’re Stressed Out appeared first on The Minimalists.

Source https://www.theminimalists.com/underpressure/

The Minimalists speak with Judah Smith about minimizing under pressure.

How do you deal with stress? Let us know in the YouTube comments.

The post Decluttering When You’re Stressed Out appeared first on The Minimalists.

AARP 2026 Tech Trends – what a difference a decade makes!

Source https://www.ageinplacetech.com/blog/aarp-2026-tech-trends-what-difference-decade-makes

As they do each year since 2016, AARP surveys the 50+ about tech.  AARP’s new Tech Trends and the 50+ offers a sharp reminder about what’s changed in tech ownership over the past decade. We have moved from desktop computers and simple cell phones, email and browsing to today. The report reflects what we can see all around us – 90% of the 50+ have smartphones, texting is their lead communication method, and 90% use social media.  Unfortunately, the report continues to frame the older a…

Source https://www.ageinplacetech.com/blog/aarp-2026-tech-trends-what-difference-decade-makes

As they do each year since 2016, AARP surveys the 50+ about tech.  AARP’s new Tech Trends and the 50+ offers a sharp reminder about what’s changed in tech ownership over the past decade. We have moved from desktop computers and simple cell phones, email and browsing to today. The report reflects what we can see all around us – 90% of the 50+ have smartphones, texting is their lead communication method, and 90% use social media.  Unfortunately, the report continues to frame the older a…

How Menopause Exposed the Hidden Trauma I Spent Years Ignoring

Source https://tinybuddha.com/blog/how-menopause-exposed-the-hidden-trauma-i-spent-years-ignoring/

“There is no way to be whole without first embracing our brokenness. Wounds transform us, if we let them.” ~Sue Monk Kidd

Menopause flagged up everything unresolved, unmet, and unchallenged and asked me to meet it with grace.

I’m not saying it was an overnight thing—more like a ten-year process of discovery, rollercoaster style. One of those “strap yourself in, no brakes, no seatbelt, possibly no survival” rides.

If I’m honest, the process is still unfolding, but with less “aaaaggggghhhhh” and more “oh.”

Having mentally swapped<span class="apple-c…

Source https://tinybuddha.com/blog/how-menopause-exposed-the-hidden-trauma-i-spent-years-ignoring/

“There is no way to be whole without first embracing our brokenness. Wounds transform us, if we let them.” ~Sue Monk Kidd

Menopause flagged up everything unresolved, unmet, and unchallenged and asked me to meet it with grace.

I’m not saying it was an overnight thing—more like a ten-year process of discovery, rollercoaster style. One of those “strap yourself in, no brakes, no seatbelt, possibly no survival” rides.

If I’m honest, the process is still unfolding, but with less “aaaaggggghhhhh” and more “oh.”

Having mentally swapped<span class="apple-c…

Overexpressing TREX1 in Macrophages Reduces Injury Following Heart Attack

Source https://www.fightaging.org/archives/2025/12/overexpressing-trex1-in-macrophages-reduces-injury-following-heart-attack/

Researchers here describe an indirect method of inducing greater resistance to damage and regeneration following a heart attack via modulation of macrophage behavior. Macrophages are innate immune cells resident in tissues that play an important role in regeneration and response to injury. The approach taken here is to grant macrophages better control over internally mislocalized DNA, escaped from either the nucleus or mitochondria into the cytosol. This provokes mechanism…

Source https://www.fightaging.org/archives/2025/12/overexpressing-trex1-in-macrophages-reduces-injury-following-heart-attack/

Researchers here describe an indirect method of inducing greater resistance to damage and regeneration following a heart attack via modulation of macrophage behavior. Macrophages are innate immune cells resident in tissues that play an important role in regeneration and response to injury. The approach taken here is to grant macrophages better control over internally mislocalized DNA, escaped from either the nucleus or mitochondria into the cytosol. This provokes mechanism…

Senior Planet talks to…Kelsey Grammer

Source https://seniorplanet.org/articles-senior-planet-kelsey-grammer/

Award-winning actor Kelsey Grammer, 70, talks about life after Cheers, Frasier, and private tragedy, his happy marriage and his newest role.

The post Senior Planet talks to…Kelsey Grammer appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-senior-planet-kelsey-grammer/

Award-winning actor Kelsey Grammer, 70, talks about life after Cheers, Frasier, and private tragedy, his happy marriage and his newest role.

The post Senior Planet talks to…Kelsey Grammer appeared first on Senior Planet from AARP.

Long Term Treatment with Mesenchymal Stem Cell Extracellular Vesicles Improves Cognitive Function in Rhesus Monkeys

Source https://www.fightaging.org/archives/2025/12/long-term-treatment-with-mesenchymal-stem-cell-extracellular-vesicles-improves-cognitive-function-in-rhesus-monkeys/

Much of the benefit of stem cell therapies results from the signals released by those cells in the short time they survive in the body following transplantation. Much of that signaling is carried by extracellular vesicles, membrane-wrapped packages of molecules. Extracellular vesicle therapies can in principle become considerably less costly than stem cell therapies, because manufacture can be centralized, and because extracellular vesicles are much more readily stored and transported, but we are not there yet. Thus while extracellular vesicle therapy is certainly available to those with the time and patience to navigate the medical tourism space, or find suppliers and a cooperative physician inside the US, the schedule of …

Source https://www.fightaging.org/archives/2025/12/long-term-treatment-with-mesenchymal-stem-cell-extracellular-vesicles-improves-cognitive-function-in-rhesus-monkeys/

Much of the benefit of stem cell therapies results from the signals released by those cells in the short time they survive in the body following transplantation. Much of that signaling is carried by extracellular vesicles, membrane-wrapped packages of molecules. Extracellular vesicle therapies can in principle become considerably less costly than stem cell therapies, because manufacture can be centralized, and because extracellular vesicles are much more readily stored and transported, but we are not there yet. Thus while extracellular vesicle therapy is certainly available to those with the time and patience to navigate the medical tourism space, or find suppliers and a cooperative physician inside the US, the schedule of …

Podcast Ep. 517 | Bad Thoughts

Source https://www.theminimalists.com/p517/

The Minimalists speak with Judah Smith about how other people’s perception of us can be upsetting, the biggest things that send people into a mental spiral, advice for minimizing when you’re stressed out, and much more.

Listen to the Episode

Apple · Spotify · Patreon

Discussed in This Episode

  • Should I read my mother’s diary after she dies?
  • What sends you into a mental spiral?
  • <span style="font-weight: 40…

Source https://www.theminimalists.com/p517/

The Minimalists speak with Judah Smith about how other people’s perception of us can be upsetting, the biggest things that send people into a mental spiral, advice for minimizing when you’re stressed out, and much more.

Listen to the Episode

Apple · Spotify · Patreon

Discussed in This Episode

  • Should I read my mother’s diary after she dies?
  • What sends you into a mental spiral?
  • <span style="font-weight: 40…

Learning to Be Seen After a Childhood Spent Disappearing

Source https://tinybuddha.com/blog/learning-to-be-seen-after-a-childhood-spent-disappearing/

“The habits you created to survive will no longer serve you when it’s time to thrive.” ~Eboni Davis

I learned early how to measure the danger in a room. With a narcissistic mother, the air could shift in an instant—her tone slicing through me, reminding me that my feelings had no place.

With an alcoholic stepfather, the threat was louder, heavier, and more unpredictable. I still remember the slam of bottles on the counter, the crack of his voice turning to fists, the way I would hold my breath in the dark, hoping the storm would pass without landing on me.

In that house, love wasn’t safe. Love was survival. And survival meant disappearing—making myself small, silent, and…

Source https://tinybuddha.com/blog/learning-to-be-seen-after-a-childhood-spent-disappearing/

“The habits you created to survive will no longer serve you when it’s time to thrive.” ~Eboni Davis

I learned early how to measure the danger in a room. With a narcissistic mother, the air could shift in an instant—her tone slicing through me, reminding me that my feelings had no place.

With an alcoholic stepfather, the threat was louder, heavier, and more unpredictable. I still remember the slam of bottles on the counter, the crack of his voice turning to fists, the way I would hold my breath in the dark, hoping the storm would pass without landing on me.

In that house, love wasn’t safe. Love was survival. And survival meant disappearing—making myself small, silent, and…

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