Source https://www.fightaging.org/archives/2023/05/glynac-supplementation-slows-cognitive-decline-in-mice/
GlyNAC supplementation involves intake of comparatively large amounts of glycine and N-acetylcysteine in order to boost levels of the antioxidant glutathione, which normally decline with age. In small human trials this proved to be a surprisingly beneficial intervention for older people when it comes to reducing inflammation and improving measures of health. Animal studies still continue, of course, and here researchers demonstrate that GlyNAC supplementation slows cognitive decline in mice.
Researchers worked with three groups of mice. Two groups were aged…
Source https://www.fightaging.org/archives/2023/05/glynac-supplementation-slows-cognitive-decline-in-mice/
GlyNAC supplementation involves intake of comparatively large amounts of glycine and N-acetylcysteine in order to boost levels of the antioxidant glutathione, which normally decline with age. In small human trials this proved to be a surprisingly beneficial intervention for older people when it comes to reducing inflammation and improving measures of health. Animal studies still continue, of course, and here researchers demonstrate that GlyNAC supplementation slows cognitive decline in mice.
Researchers worked with three groups of mice. Two groups were aged…
Source https://www.fightaging.org/archives/2023/05/knowing-both-a-great-deal-and-too-little-about-the-mechanisms-of-sarcopenia/
Today’s open access paper is a tour of the better known mechanisms of post-translational modification of proteins, and their relevance to the universal age-related loss of muscle mass and strength, the onset of sarcopenia. It is a good example of the state of knowledge in much of the life sciences, where it is possible to know both a great deal and very little about an important topic such as maintenance of muscle tissue.
Thus one can find any number of papers in which specific mechanisms of post-translational modification when applied to specific proteins are investigated in connection to the regulation of muscle growth or maintenance of structures important to muscle strength, such as neuromuscular junctions. But at the end of the d…
Source https://www.fightaging.org/archives/2023/05/knowing-both-a-great-deal-and-too-little-about-the-mechanisms-of-sarcopenia/
Today’s open access paper is a tour of the better known mechanisms of post-translational modification of proteins, and their relevance to the universal age-related loss of muscle mass and strength, the onset of sarcopenia. It is a good example of the state of knowledge in much of the life sciences, where it is possible to know both a great deal and very little about an important topic such as maintenance of muscle tissue.
Thus one can find any number of papers in which specific mechanisms of post-translational modification when applied to specific proteins are investigated in connection to the regulation of muscle growth or maintenance of structures important to muscle strength, such as neuromuscular junctions. But at the end of the d…
Source https://www.fightaging.org/archives/2023/05/measures-of-biological-age-largely-correlate-with-cancer-risk/
Cancer is an age-related condition. With age, there is a greater background of mutational damage that spreads throughout tissues. Greater inflammatory, pro-growth signaling by lingering senescent cells makes the environment more hospitable for cancerous growth once it is underway. The aging immune system becomes ever less able to destroy precancerous and cancerous cells rapidly enough to stop a cancer in its earliest stages.
Thus we should expect people who show an accelerated biological age to exhibit a greater risk of cancer, and this is largely the case. Most measu…
Source https://www.fightaging.org/archives/2023/05/measures-of-biological-age-largely-correlate-with-cancer-risk/
Cancer is an age-related condition. With age, there is a greater background of mutational damage that spreads throughout tissues. Greater inflammatory, pro-growth signaling by lingering senescent cells makes the environment more hospitable for cancerous growth once it is underway. The aging immune system becomes ever less able to destroy precancerous and cancerous cells rapidly enough to stop a cancer in its earliest stages.
Thus we should expect people who show an accelerated biological age to exhibit a greater risk of cancer, and this is largely the case. Most measu…
Source https://tinybuddha.com/blog/one-thing-we-need-to-survive-crisis-loss-and-trauma/
“What man actually needs is not a tensionless state but rather the striving and struggling for a worthwhile goal, a freely chosen task.” ~Viktor Frankl
A couple of years ago, I was sitting in my little mountain cottage, writing away on a new novel. It was a cold and dark February afternoon. So, first, I felt pleasantly surprised when I saw something bright lighting up behind me: I thought it was the sun coming out. But when I turned around, I noticed that my porch was on fire!
Before I knew what was happening, I was standing out in the snow in my slippers, looking back at the entrance and facade completely engulfed by flames.
It was like a near-death experience. My mind quickly took an inventory of all the things that were inside the cottage now burning…
Source https://tinybuddha.com/blog/one-thing-we-need-to-survive-crisis-loss-and-trauma/
“What man actually needs is not a tensionless state but rather the striving and struggling for a worthwhile goal, a freely chosen task.” ~Viktor Frankl
A couple of years ago, I was sitting in my little mountain cottage, writing away on a new novel. It was a cold and dark February afternoon. So, first, I felt pleasantly surprised when I saw something bright lighting up behind me: I thought it was the sun coming out. But when I turned around, I noticed that my porch was on fire!
Before I knew what was happening, I was standing out in the snow in my slippers, looking back at the entrance and facade completely engulfed by flames.
It was like a near-death experience. My mind quickly took an inventory of all the things that were inside the cottage now burning…
Source https://www.fightaging.org/archives/2023/05/the-thioredoxin-antioxidant-system-in-aging-and-longevity/
Sabotaging antioxidant systems can shorten life span in model organisms, but that doesn’t necessarily imply that one can lengthen life by improving on biological antioxidant capacity. Yes, oxidative stress rises with age, and the presence of too many oxidizing molecules is harmful to a cell, but the presence of those oxidizing molecules and the damage they cause to cellular machinery is also a signal that produces greater cell maintenance and other beneficial outcomes. Cellular biochemistry is complicated, and it is rarely the case that relationships are simple and linear. General delivery of antioxidants as supplements has been shown to have no effect, or even mildly negative effects, on long-te…
Source https://www.fightaging.org/archives/2023/05/the-thioredoxin-antioxidant-system-in-aging-and-longevity/
Sabotaging antioxidant systems can shorten life span in model organisms, but that doesn’t necessarily imply that one can lengthen life by improving on biological antioxidant capacity. Yes, oxidative stress rises with age, and the presence of too many oxidizing molecules is harmful to a cell, but the presence of those oxidizing molecules and the damage they cause to cellular machinery is also a signal that produces greater cell maintenance and other beneficial outcomes. Cellular biochemistry is complicated, and it is rarely the case that relationships are simple and linear. General delivery of antioxidants as supplements has been shown to have no effect, or even mildly negative effects, on long-te…
Source https://seniorplanet.org/articles-creative-tech-crazy-apps/
Paper airplanes, sandscapes, comics – you’ll never believe what these crazy apps can help you create!
The post Creative Tech: Go Crazy – Creatively – with these Apps appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-creative-tech-crazy-apps/
Paper airplanes, sandscapes, comics – you’ll never believe what these crazy apps can help you create!
The post Creative Tech: Go Crazy – Creatively – with these Apps appeared first on Senior Planet from AARP.
…
Source https://www.fightaging.org/archives/2023/05/the-new-alzheimers-therapies-are-not-what-one-would-call-successful/
The first batch of immunotherapies demonstrated to be capable of clearing extracellular amyloid-β from the brain have performed poorly in late stage Alzheimer’s patients. Data is beginning to emerge for their ability to modestly slow down the progression of the condition at earlier stages, however. This somewhat fits with the amyloid cascade hypothesis, in that it is evidence to support the idea that amyloid-β is no longer important to disease progression once the condition has reached the stage of becoming a feedback loop involving tau aggregation, <a href="https://en.wikipedia…
Source https://www.fightaging.org/archives/2023/05/the-new-alzheimers-therapies-are-not-what-one-would-call-successful/
The first batch of immunotherapies demonstrated to be capable of clearing extracellular amyloid-β from the brain have performed poorly in late stage Alzheimer’s patients. Data is beginning to emerge for their ability to modestly slow down the progression of the condition at earlier stages, however. This somewhat fits with the amyloid cascade hypothesis, in that it is evidence to support the idea that amyloid-β is no longer important to disease progression once the condition has reached the stage of becoming a feedback loop involving tau aggregation, <a href="https://en.wikipedia…
Source https://www.fightaging.org/archives/2023/05/calorie-restriction-slows-loss-of-memory-function-in-old-rats/
Calorie restriction, the practice of consuming fewer calories while still maintaining an optimal intake of micronutrients, improves near all aspects of health and slows the progression of aging. This outcome appears to largely result from improved autophagy, or at least it is the case that functional autophagy is required for these benefits to occur in animal models. The relative extension of life span resulting from calorie restriction is much greater in short-lived species, as much as 40% in mice, but most likely only a few ad…
Source https://www.fightaging.org/archives/2023/05/calorie-restriction-slows-loss-of-memory-function-in-old-rats/
Calorie restriction, the practice of consuming fewer calories while still maintaining an optimal intake of micronutrients, improves near all aspects of health and slows the progression of aging. This outcome appears to largely result from improved autophagy, or at least it is the case that functional autophagy is required for these benefits to occur in animal models. The relative extension of life span resulting from calorie restriction is much greater in short-lived species, as much as 40% in mice, but most likely only a few ad…
Source https://minimalistbaker.com/charred-shishito-mango-salsa/
Mango salsa just got even better thanks to charred shishito peppers! The two combine for a sweet, smoky salsa that’s ready to elevate your tortilla chips, tacos, bowls, roasted plantains, and so much more.
Just 8 ingredients and 25 minutes required for this easy flavor bomb. Let’s make salsa!
How to Make Mango Shishito Pepper Salsa
This salsa begins with one of our favorite methods for cooking shishitos: pan searing until charred and smoky!
Charred Shishito Mango Salsa from Minimalist Baker →
…
Source https://minimalistbaker.com/charred-shishito-mango-salsa/
Mango salsa just got even better thanks to charred shishito peppers! The two combine for a sweet, smoky salsa that’s ready to elevate your tortilla chips, tacos, bowls, roasted plantains, and so much more.
Just 8 ingredients and 25 minutes required for this easy flavor bomb. Let’s make salsa!
How to Make Mango Shishito Pepper Salsa
This salsa begins with one of our favorite methods for cooking shishitos: pan searing until charred and smoky!
Charred Shishito Mango Salsa from Minimalist Baker →
…
Source https://tinybuddha.com/blog/9-self-guided-meditation-courses-to-deepen-your-practice-and-supercharge-your-spiritual-growth/
In a culture that teaches us we need to prove our worth through achievements, it can be challenging to prioritize peace, well-being, and spiritual growth.
We’re bombarded by marketing messages that tell us we’ll be enough, if only we “buy this—do this—look like this,” making it difficult to simply relax in who we are and feel a sense of contentment in our lives. But there is a way out of this cycle of discontent, anxiety, and constant striving.
If you’re yearning to connect with life more deeply and feel a sense of greater peace and acceptance, I highly recommend developing a regular meditation practice.
Before I began meditating, I was constantly agitated, anxious…
Source https://tinybuddha.com/blog/9-self-guided-meditation-courses-to-deepen-your-practice-and-supercharge-your-spiritual-growth/
In a culture that teaches us we need to prove our worth through achievements, it can be challenging to prioritize peace, well-being, and spiritual growth.
We’re bombarded by marketing messages that tell us we’ll be enough, if only we “buy this—do this—look like this,” making it difficult to simply relax in who we are and feel a sense of contentment in our lives. But there is a way out of this cycle of discontent, anxiety, and constant striving.
If you’re yearning to connect with life more deeply and feel a sense of greater peace and acceptance, I highly recommend developing a regular meditation practice.
Before I began meditating, I was constantly agitated, anxious…