Source https://www.fightaging.org/archives/2023/05/protein-aggregation-in-the-aging-heart/
As noted in this open access paper, protein misfolding and aggregation is a body-wide feature of aging, not only associated with the brain and neurodegenerative conditions. In the case of the heart, it is becoming apparent that misfolding of transthyretin to form amyloid can play a role in heart disease, and this form of amyloidosis may grow to be the majority cause of death for supercentenarians. The paper here is a more general tour of relevant mechanisms rather than a focus on any one specific protein, but is nonet…
Source https://www.fightaging.org/archives/2023/05/protein-aggregation-in-the-aging-heart/
As noted in this open access paper, protein misfolding and aggregation is a body-wide feature of aging, not only associated with the brain and neurodegenerative conditions. In the case of the heart, it is becoming apparent that misfolding of transthyretin to form amyloid can play a role in heart disease, and this form of amyloidosis may grow to be the majority cause of death for supercentenarians. The paper here is a more general tour of relevant mechanisms rather than a focus on any one specific protein, but is nonet…
Source https://greatist.com/discover/breath-play
Breath play is about controlling breathing for erotic arousal. It requires extreme caution and knowledge of the risks involved. Before you explore breath play, you must establish clear communication, trust, and boundaries with your partner.
Although there are plenty of kinky possibilities out there, breath play (aka erotic asphyxiation) is one of the most exhilarating — and dangerous.
Breath play is a form of sexual exploration that involves intentionally restricting oxygen to get your heart racing and your senses tingling. It’s about pushing boundaries, letting go of inhibitions, and discovering new levels of pleasure and intimacy. And yes, it may involve choking, but there are other options, like breath swapping or nose pinching.
But… you must approach breath play with caution and care, only engaging with someone you trust and with proper education on safety techniques. You…
Source https://greatist.com/discover/breath-play
Breath play is about controlling breathing for erotic arousal. It requires extreme caution and knowledge of the risks involved. Before you explore breath play, you must establish clear communication, trust, and boundaries with your partner.
Although there are plenty of kinky possibilities out there, breath play (aka erotic asphyxiation) is one of the most exhilarating — and dangerous.
Breath play is a form of sexual exploration that involves intentionally restricting oxygen to get your heart racing and your senses tingling. It’s about pushing boundaries, letting go of inhibitions, and discovering new levels of pleasure and intimacy. And yes, it may involve choking, but there are other options, like breath swapping or nose pinching.
But… you must approach breath play with caution and care, only engaging with someone you trust and with proper education on safety techniques. You…
Source https://seniorplanet.org/articles-favorite-tv-moms/
They were among the most beloved moms on TV, demonstrating the chaos – and hilarity – of family life. Here’s a look at some of our favorite TV moms.
The post Favorite TV Moms appeared first on Senior Planet from AARP.
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Source https://seniorplanet.org/articles-favorite-tv-moms/
They were among the most beloved moms on TV, demonstrating the chaos – and hilarity – of family life. Here’s a look at some of our favorite TV moms.
The post Favorite TV Moms appeared first on Senior Planet from AARP.
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Source https://tinybuddha.com/blog/how-i-found-forgiveness-and-compassion-when-i-felt-hurt-and-betrayed/
“I can bear any pain as long as it has meaning.” ~Haruki Murakami
I’ve always felt like someone on the outside. Despite having these feelings I’ve been relatively successful at playing the game of life, and have survived through school, university, and the workplace—although, at times, working so hard to ’survive’ has impacted my emotional well-being.
I have been lucky enough to have healthy and supportive relationships with a few loved ones who have accepted me as I am (quirks and all). To anyone else I’ve come across, I suspect I’ve been perceived as inexplicably normal and inoffensive.
Like many of us who have suffered with our mental health, I’ve always been curious to learn more about who I am beyond the surface level experiences of life…
Source https://tinybuddha.com/blog/how-i-found-forgiveness-and-compassion-when-i-felt-hurt-and-betrayed/
“I can bear any pain as long as it has meaning.” ~Haruki Murakami
I’ve always felt like someone on the outside. Despite having these feelings I’ve been relatively successful at playing the game of life, and have survived through school, university, and the workplace—although, at times, working so hard to ’survive’ has impacted my emotional well-being.
I have been lucky enough to have healthy and supportive relationships with a few loved ones who have accepted me as I am (quirks and all). To anyone else I’ve come across, I suspect I’ve been perceived as inexplicably normal and inoffensive.
Like many of us who have suffered with our mental health, I’ve always been curious to learn more about who I am beyond the surface level experiences of life…
Source https://www.fightaging.org/archives/2023/05/on-the-optimization-of-exercise-for-long-term-health-and-longevity/
How much optimization of exercise is a reasonable goal, given what is presently known? Today’s open access paper makes the fair point that our hunter-gatherer evolution matches us to a certain strategy, meaning a lot of moderate exercise leavened with a smaller amount of intermittent vigorous exercise. Epidemiological evidence supports the merits of a lot of moderate exercise, while suggesting that a lot of vigorous exercise doesn’t add that much to the benefits, and it is actually possible to exercise too much.
The dose-response curve for exercise is one in which small amounts of effort are <a href="https://www.fightaging.org/archives/2018/08/how-little-exercise-is-needed…
Source https://www.fightaging.org/archives/2023/05/on-the-optimization-of-exercise-for-long-term-health-and-longevity/
How much optimization of exercise is a reasonable goal, given what is presently known? Today’s open access paper makes the fair point that our hunter-gatherer evolution matches us to a certain strategy, meaning a lot of moderate exercise leavened with a smaller amount of intermittent vigorous exercise. Epidemiological evidence supports the merits of a lot of moderate exercise, while suggesting that a lot of vigorous exercise doesn’t add that much to the benefits, and it is actually possible to exercise too much.
The dose-response curve for exercise is one in which small amounts of effort are <a href="https://www.fightaging.org/archives/2018/08/how-little-exercise-is-needed…
Source https://www.ageinplacetech.com/blog/ai-opportunity-more-and-better-services
Wondering if there’s any news about AI? Just from yesterday, May 3, 2023 – that list goes on and on. MIT Technology Review packs all the AI news that’s fit to pack into an up-to-the-minute digest. The New York Times attempts similar for the uninitiated. So does the <a href="https://www.wsj.com/news/collection/artificial-intelligence-r…
Source https://www.ageinplacetech.com/blog/ai-opportunity-more-and-better-services
Wondering if there’s any news about AI? Just from yesterday, May 3, 2023 – that list goes on and on. MIT Technology Review packs all the AI news that’s fit to pack into an up-to-the-minute digest. The New York Times attempts similar for the uninitiated. So does the <a href="https://www.wsj.com/news/collection/artificial-intelligence-r…
Source https://www.fightaging.org/archives/2023/05/physical-fitness-slows-accumulation-of-senescent-cells-to-better-maintain-vascular-function/
To the degree that regular exercise and maintenance physical fitness preserve health in later life, it must be slowing the fundamental mechanisms of aging. One of those mechanisms is the accumulation of senescent cells, which emerges due to a growing imbalance between the pace of creation and pace of destruction. Exercise is known to improve autophagy, and this in turn slows the pace of creation of senescent cells. Exercise also improves immune function. Which of these effects are more important in the case of the age-related burden of senescent cells is an open question.
Blood vessels are key conduits for the transport of blood and circulating …
Source https://www.fightaging.org/archives/2023/05/physical-fitness-slows-accumulation-of-senescent-cells-to-better-maintain-vascular-function/
To the degree that regular exercise and maintenance physical fitness preserve health in later life, it must be slowing the fundamental mechanisms of aging. One of those mechanisms is the accumulation of senescent cells, which emerges due to a growing imbalance between the pace of creation and pace of destruction. Exercise is known to improve autophagy, and this in turn slows the pace of creation of senescent cells. Exercise also improves immune function. Which of these effects are more important in the case of the age-related burden of senescent cells is an open question.
Blood vessels are key conduits for the transport of blood and circulating …
Source https://minimalistbaker.com/creamy-vegan-white-bean-queso/
What can’t you turn into queso!? We’ve made cashews and eggplant into “cheesy” queso-like dips, so why not try a protein- and fiber-packed twist with white beans? Spoiler alert: Success! Friends, meet our new favorite creamy dip: white bean queso!
It’s vegan, gluten-free, SO satisfying + snack-able, and easy to make, too! Just 9 ingredients and 30 minutes required. Grab your favorite chips and let’s do this!
Creamy Vegan White Bean Queso from Minimalist Baker →
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Source https://minimalistbaker.com/creamy-vegan-white-bean-queso/
What can’t you turn into queso!? We’ve made cashews and eggplant into “cheesy” queso-like dips, so why not try a protein- and fiber-packed twist with white beans? Spoiler alert: Success! Friends, meet our new favorite creamy dip: white bean queso!
It’s vegan, gluten-free, SO satisfying + snack-able, and easy to make, too! Just 9 ingredients and 30 minutes required. Grab your favorite chips and let’s do this!
Creamy Vegan White Bean Queso from Minimalist Baker →
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Source https://seniorplanet.org/articles-allergies/
If you have them, you know. Allergy season can be miserable – here’s how to find relief.
The post Allergies! appeared first on Senior Planet from AARP.
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Source https://seniorplanet.org/articles-allergies/
If you have them, you know. Allergy season can be miserable – here’s how to find relief.
The post Allergies! appeared first on Senior Planet from AARP.
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Source https://www.fightaging.org/archives/2023/05/on-the-aging-of-microglia/
Microglia are innate immune cells of the brain. They are analogous to macrophages elsewhere in the body, responsible for clearing up debris, destroying pathogens and problem cells, and participating in regeneration. They also undertake an arguably larger portfolio of tissue maintenance tasks that are related to neural function and synaptic connections.
With advancing age, the microglial population of the brain becomes more activated and inflammatory in response to a tissue environment that contains more signs of damage and cell stress. As is true of <a href="https://en.wikipedia…
Source https://www.fightaging.org/archives/2023/05/on-the-aging-of-microglia/
Microglia are innate immune cells of the brain. They are analogous to macrophages elsewhere in the body, responsible for clearing up debris, destroying pathogens and problem cells, and participating in regeneration. They also undertake an arguably larger portfolio of tissue maintenance tasks that are related to neural function and synaptic connections.
With advancing age, the microglial population of the brain becomes more activated and inflammatory in response to a tissue environment that contains more signs of damage and cell stress. As is true of <a href="https://en.wikipedia…
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