Source https://www.fightaging.org/archives/2022/11/low-to-moderate-stress-improves-memory-function/
Psychological stress has a dose response curve in which it is beneficial for some functions at low levels, it seems. This is not a complete surprise, given that hormesis seems to be a universal phenomenon. Mild or short-lived stress produces a lasting protective reaction that more than compensates for any harms caused by the stress, improving cell and tissue function. Here researchers show evidence for low levels of stress to improve memory. We might suspect this effect to be mediated by increased blood flow to the brain, given the copious evidence for improved memory function to result from increased cerebral blood flow, such as resulting from exercise. Port…
Source https://www.fightaging.org/archives/2022/11/low-to-moderate-stress-improves-memory-function/
Psychological stress has a dose response curve in which it is beneficial for some functions at low levels, it seems. This is not a complete surprise, given that hormesis seems to be a universal phenomenon. Mild or short-lived stress produces a lasting protective reaction that more than compensates for any harms caused by the stress, improving cell and tissue function. Here researchers show evidence for low levels of stress to improve memory. We might suspect this effect to be mediated by increased blood flow to the brain, given the copious evidence for improved memory function to result from increased cerebral blood flow, such as resulting from exercise. Port…
Source https://www.fightaging.org/archives/2022/11/when-does-the-heart-become-larger-versus-smaller-in-old-age/
As you may know, the aging heart often exhibits ventricular hypertrophy, an enlargement and weakening of the muscle. This appears driven in large part by the increased burden of cellular senescence in later life, given reversal of hypertrophy observed after senolytic treatment in old animals. This hypertrophy can also be thought as a downstream consequence of hypertension, but biology is rarely so simple as to have a single line of cause and effect. As noted in this paper, people lose muscle mass and strength with age, leading to the weakness and frai…
Source https://www.fightaging.org/archives/2022/11/when-does-the-heart-become-larger-versus-smaller-in-old-age/
As you may know, the aging heart often exhibits ventricular hypertrophy, an enlargement and weakening of the muscle. This appears driven in large part by the increased burden of cellular senescence in later life, given reversal of hypertrophy observed after senolytic treatment in old animals. This hypertrophy can also be thought as a downstream consequence of hypertension, but biology is rarely so simple as to have a single line of cause and effect. As noted in this paper, people lose muscle mass and strength with age, leading to the weakness and frai…
Source https://www.fightaging.org/archives/2022/11/arguing-for-well-explored-approaches-to-slow-aging-to-not-in-fact-slow-aging/
Today’s open access paper mounts an interesting argument, based on the use of a large data set for phenotypic aging in mice. They looked at transcriptomic and proteomic data for a sizable number of genes in a variety of different tissues, then grouping these into phenotypes by related function, or relation to specific age-related declines. Differences in expression by age in these phenotypic groups of genes were observed directly in mice and in human data sets.
The researchers then looked the effects on phenotypes of a few very well studied interventions widely thought to slow aging in mice: growth hormone signaling inhibition, <a…
Source https://www.fightaging.org/archives/2022/11/arguing-for-well-explored-approaches-to-slow-aging-to-not-in-fact-slow-aging/
Today’s open access paper mounts an interesting argument, based on the use of a large data set for phenotypic aging in mice. They looked at transcriptomic and proteomic data for a sizable number of genes in a variety of different tissues, then grouping these into phenotypes by related function, or relation to specific age-related declines. Differences in expression by age in these phenotypic groups of genes were observed directly in mice and in human data sets.
The researchers then looked the effects on phenotypes of a few very well studied interventions widely thought to slow aging in mice: growth hormone signaling inhibition, <a…
Source https://www.fightaging.org/archives/2022/11/making-senescent-cells-glow-in-vivo/
Currently there is some debate over whether the initial markers used to detect senescent cells, such as as senescence-associated β-galactosidase and P16 expression, are general enough across cell types and specific enough to senescent cells for all uses in research and clinical development. Nonetheless, these markers are well known and the efficiency of senolytic treatments that clear senescent cells does appear to be measurable this way. Greater convenience in that measurement is always useful: at present, the state of the art involves biopsies and post-mortem t…
Source https://www.fightaging.org/archives/2022/11/making-senescent-cells-glow-in-vivo/
Currently there is some debate over whether the initial markers used to detect senescent cells, such as as senescence-associated β-galactosidase and P16 expression, are general enough across cell types and specific enough to senescent cells for all uses in research and clinical development. Nonetheless, these markers are well known and the efficiency of senolytic treatments that clear senescent cells does appear to be measurable this way. Greater convenience in that measurement is always useful: at present, the state of the art involves biopsies and post-mortem t…
Source https://www.fightaging.org/archives/2022/11/to-what-degree-can-cell-therapies-rebuild-the-aging-brain/
Repair of the aging brain is perhaps the most important of goals in regenerative medicine. We are the data that is stored in some way within the small-scale structures of our brain tissue, and so the options for outright replacement of brain cells and tissues are somewhat constrained. As a thought experiment, it is in principle possible, given significant progress in biotechnology, to manufacture a cloned body to receive a transplanted brain. All of the steps needed either already happen in nature, such as the growth of bodies without brains, and would need control and direction, or have been crudely demonstrated in animal studies, such as brain transplants, albeit with major limitations and risk of failure. There may well be little gain in transplanting an aged brain if it cannot be repaired, however.
In any case, my v…
Source https://www.fightaging.org/archives/2022/11/to-what-degree-can-cell-therapies-rebuild-the-aging-brain/
Repair of the aging brain is perhaps the most important of goals in regenerative medicine. We are the data that is stored in some way within the small-scale structures of our brain tissue, and so the options for outright replacement of brain cells and tissues are somewhat constrained. As a thought experiment, it is in principle possible, given significant progress in biotechnology, to manufacture a cloned body to receive a transplanted brain. All of the steps needed either already happen in nature, such as the growth of bodies without brains, and would need control and direction, or have been crudely demonstrated in animal studies, such as brain transplants, albeit with major limitations and risk of failure. There may well be little gain in transplanting an aged brain if it cannot be repaired, however.
In any case, my v…
Source https://greatist.com/eat/new-years-eve-appetizers
Whether your NYE looks like champagne-soaked kisses at midnight in your sparkliest frock or hosting friends to watch fireworks at home (🙋♀️), it’s worth turning up the razzle-dazzle with a tasty spread of snacks.
On the hunt for New Year’s Eve appetizers? Your search stops here. We’ve scoured the internet for 41 apps to cover anything you’re craving.
41 New Year’s Eve appetizers
So, what’s on the menu this New Year’s Eve? Whatever you want, TBH. Whether your tastes run fancy-schmancy or lean toward easy-peasy, we’ve got you covered.
Source https://greatist.com/eat/new-years-eve-appetizers
Whether your NYE looks like champagne-soaked kisses at midnight in your sparkliest frock or hosting friends to watch fireworks at home (🙋♀️), it’s worth turning up the razzle-dazzle with a tasty spread of snacks.
On the hunt for New Year’s Eve appetizers? Your search stops here. We’ve scoured the internet for 41 apps to cover anything you’re craving.
41 New Year’s Eve appetizers
So, what’s on the menu this New Year’s Eve? Whatever you want, TBH. Whether your tastes run fancy-schmancy or lean toward easy-peasy, we’ve got you covered.
Source https://tinybuddha.com/blog/4-things-i-needed-to-accept-to-let-go-and-heal-after-trauma/
TRIGGER WARNING: This post references sexual abuse and may be triggered to some people.
“The truth is, unless you let go, unless you forgive yourself, unless you forgive the situation, unless you realize that the situation is over, you cannot move forward.” ~Steve Maraboli
My family immigrated to the U.S. from India when I was sixteen. Being Indian, my traditional family expected me to have an arranged marriage.
At twenty-two, as a graduate music student, I fell in love with an American man. When my family found out about our secret relationship, they took me back to India and put me under house arrest. For a year.
That year of imprisonment and isolation was severely traumatizing. I shut down from my acute distress and pain. I dissocia…
Source https://tinybuddha.com/blog/4-things-i-needed-to-accept-to-let-go-and-heal-after-trauma/
TRIGGER WARNING: This post references sexual abuse and may be triggered to some people.
“The truth is, unless you let go, unless you forgive yourself, unless you forgive the situation, unless you realize that the situation is over, you cannot move forward.” ~Steve Maraboli
My family immigrated to the U.S. from India when I was sixteen. Being Indian, my traditional family expected me to have an arranged marriage.
At twenty-two, as a graduate music student, I fell in love with an American man. When my family found out about our secret relationship, they took me back to India and put me under house arrest. For a year.
That year of imprisonment and isolation was severely traumatizing. I shut down from my acute distress and pain. I dissocia…
Source https://seniorplanet.org/get-social-and-volunteer-2/
Volunteering – even doing it online – is a great way to meet new people and offers surprising health benefits.
The post Get Social – and Volunteer! appeared first on Senior Planet from AARP.
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Source https://seniorplanet.org/get-social-and-volunteer-2/
Volunteering – even doing it online – is a great way to meet new people and offers surprising health benefits.
The post Get Social – and Volunteer! appeared first on Senior Planet from AARP.
…
AI matters for older adults. Over the last few years, a growing number of applications of AI and machine learning have entered the market of