It is never too late to start
We read the section entitled “Seeds” this week. Let us know what you think in the comments below or the Book Lovers Club on Senior Planet Community!
The post Senior Planet Book Club: <em>Radical Hope: Letters of Love and Dissent in Dangerous Times</em> edited by Carolina de Robertis (Week 4) appeared first on Senior Planet from AARP.
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We read the section entitled “Seeds” this week. Let us know what you think in the comments below or the Book Lovers Club on Senior Planet Community!
The post Senior Planet Book Club: <em>Radical Hope: Letters of Love and Dissent in Dangerous Times</em> edited by Carolina de Robertis (Week 4) appeared first on Senior Planet from AARP.
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Source https://www.fightaging.org/archives/2022/07/alcat1-in-age-related-mitochondrial-dysfunction/
One should always be somewhat dubious when researchers claim the primacy of any single mechanism in age-related dysfunction. It is one thing to demonstrate that a mechanism exists and is damaging, and quite another to show that it provides a significant contribution to aging in animal models or humans. Aging is enormously complex, and it has traditionally proven very challenging to repair or ameliorate just one mechanism in isolation, in order to see what happens. Bear this in mind while reading this otherwise interesting paper on the function of ALCAT1 in age-related mitochondrial dysfunction.
Cardiolipin (CL) is a <a href…
Source https://www.fightaging.org/archives/2022/07/alcat1-in-age-related-mitochondrial-dysfunction/
One should always be somewhat dubious when researchers claim the primacy of any single mechanism in age-related dysfunction. It is one thing to demonstrate that a mechanism exists and is damaging, and quite another to show that it provides a significant contribution to aging in animal models or humans. Aging is enormously complex, and it has traditionally proven very challenging to repair or ameliorate just one mechanism in isolation, in order to see what happens. Bear this in mind while reading this otherwise interesting paper on the function of ALCAT1 in age-related mitochondrial dysfunction.
Cardiolipin (CL) is a <a href…
Source https://tinybuddha.com/blog/the-missing-step-to-making-your-dream-come-true/
“A dream written down with a date becomes a GOAL. A goal broken down into steps becomes a PLAN. A plan backed by ACTION makes your dreams come true.” ~Greg Reid
We all have dreams, some of them really big. And if we are serious about achieving these dreams, the next logical step is to set a goal, make a plan, and start taking action.
But we are missing out on one very important step in the dream-creating journey.
This step is one that has taken me, personally, two decades to come to realize. And my first clue came from my kids’ bedtime story book, of all places!
Down in the depths of the ocean lived a sad and lonely whale who spent his days searching and searching for the next shiny object, never feeling complete or fulfilled in his quest for more. Then one …
Source https://tinybuddha.com/blog/the-missing-step-to-making-your-dream-come-true/
“A dream written down with a date becomes a GOAL. A goal broken down into steps becomes a PLAN. A plan backed by ACTION makes your dreams come true.” ~Greg Reid
We all have dreams, some of them really big. And if we are serious about achieving these dreams, the next logical step is to set a goal, make a plan, and start taking action.
But we are missing out on one very important step in the dream-creating journey.
This step is one that has taken me, personally, two decades to come to realize. And my first clue came from my kids’ bedtime story book, of all places!
Down in the depths of the ocean lived a sad and lonely whale who spent his days searching and searching for the next shiny object, never feeling complete or fulfilled in his quest for more. Then one …
A growing body of academic work is focused on the activity of transposable elements in degenerative aging, and some of these projects may produce approaches to therapy based on suppressing this activity. Transposable elements are DNA sequences capable of copying themselves within the genome, thought to be the result of ancient viral infections, but which contribute to evolution by providing a ready path to mutational change. Transposable elements are suppressed in youth, but with age the regulation of gene expression becomes more ragged, and transposable elements exhibit ever greater activity. This is supposed by many researchers to contribute to degenerative aging in much the same way <a href="https://www.fightaging.org/archives/2020/05/somatic-chromo…
A growing body of academic work is focused on the activity of transposable elements in degenerative aging, and some of these projects may produce approaches to therapy based on suppressing this activity. Transposable elements are DNA sequences capable of copying themselves within the genome, thought to be the result of ancient viral infections, but which contribute to evolution by providing a ready path to mutational change. Transposable elements are suppressed in youth, but with age the regulation of gene expression becomes more ragged, and transposable elements exhibit ever greater activity. This is supposed by many researchers to contribute to degenerative aging in much the same way <a href="https://www.fightaging.org/archives/2020/05/somatic-chromo…
A great deal of time and effort was required to achieve the first pig to human heart transplant, including the production of genetically engineered pigs that lack the cell features that provoke rejection, and which minimize the presence of porcine viruses. Nonetheless, the first transplanted heart failed after some weeks for reasons that are yet to be determined, undergoing widespread cell death. This suggests that the remainder of the path towards viable xenotransplantation will be longer than hoped. As a strategy, xenotransplantation competes with work on the production of organs built from patient cells, an approach that will likely take at least as long to b…
A great deal of time and effort was required to achieve the first pig to human heart transplant, including the production of genetically engineered pigs that lack the cell features that provoke rejection, and which minimize the presence of porcine viruses. Nonetheless, the first transplanted heart failed after some weeks for reasons that are yet to be determined, undergoing widespread cell death. This suggests that the remainder of the path towards viable xenotransplantation will be longer than hoped. As a strategy, xenotransplantation competes with work on the production of organs built from patient cells, an approach that will likely take at least as long to b…
Source https://seniorplanet.org/apps-for-that-summer-road-trip/
Savvy road trippers know that a smartphone is their best friend on the road – and there are more options besides Google Maps.
The post Apps for that Summer Road Trip appeared first on Senior Planet from AARP.
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Source https://seniorplanet.org/apps-for-that-summer-road-trip/
Savvy road trippers know that a smartphone is their best friend on the road – and there are more options besides Google Maps.
The post Apps for that Summer Road Trip appeared first on Senior Planet from AARP.
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The immune system becomes ever more inflammatory with advancing age, a state known as inflammaging, even as it loses competence in destroying pathogens and unwanted cells. This sustained, unresolved inflammation is harmful, the cause of numerous harmful changes in cell function and failures of tissue maintenance. It accelerates the onset and progression of all of the common age-related conditions. This is caused in part by the pro-inflammatory signaling of senescent cells, present in increasing numbers in the aged body. Another important contribution, and a focus in today’s open access paper, is the activation of <a h…
The immune system becomes ever more inflammatory with advancing age, a state known as inflammaging, even as it loses competence in destroying pathogens and unwanted cells. This sustained, unresolved inflammation is harmful, the cause of numerous harmful changes in cell function and failures of tissue maintenance. It accelerates the onset and progression of all of the common age-related conditions. This is caused in part by the pro-inflammatory signaling of senescent cells, present in increasing numbers in the aged body. Another important contribution, and a focus in today’s open access paper, is the activation of <a h…
As scientists note here, a number of reptilian and amphibian species exhibit negligible senescence, in that their mortality risk does not increase with age, at least not until very late life. The question has always been whether there is anything that can be learned from the cellular biochemistry of these species that can serve as the basis for enhancement therapies in mammals. There is no assurance that the basis of negligible senescence in any given species is simple enough to be useful. There is no assurance that even a simple difference could be safely ported over into mammalian biology given the biotechnology of the next few decades. Nonetheless, it is a topic of interest in the research community, a way to broaden the understanding of how differences in genetics and metabolism give rise to sizable differ…
As scientists note here, a number of reptilian and amphibian species exhibit negligible senescence, in that their mortality risk does not increase with age, at least not until very late life. The question has always been whether there is anything that can be learned from the cellular biochemistry of these species that can serve as the basis for enhancement therapies in mammals. There is no assurance that the basis of negligible senescence in any given species is simple enough to be useful. There is no assurance that even a simple difference could be safely ported over into mammalian biology given the biotechnology of the next few decades. Nonetheless, it is a topic of interest in the research community, a way to broaden the understanding of how differences in genetics and metabolism give rise to sizable differ…
Source https://seniorplanet.org/open-thread-shopping-sprees-and-retail-therapy/
Sometimes the simple things…aren’t so simple – like a shopping spree with a good friend. It’s really retail therapy. What do you buy that lifts you?
The post Open Thread: Shopping Sprees and Retail Therapy appeared first on Senior Planet from AARP.
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Source https://seniorplanet.org/open-thread-shopping-sprees-and-retail-therapy/
Sometimes the simple things…aren’t so simple – like a shopping spree with a good friend. It’s really retail therapy. What do you buy that lifts you?
The post Open Thread: Shopping Sprees and Retail Therapy appeared first on Senior Planet from AARP.
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Researchers here report on an investigation of mechanisms by which aged human skin is improved in function when transplanted onto young immunocompromised mice. They identified VEGF-A as a factor involved in this improvement, and showed that delivering VEGF-A to human skin models can reduce signatures of aging. This is interesting, as a number of skin conditions exhibit high levels of VEGF-A, and are treated by therapies that are shown to inhibit VEGF-A in addition to other effects. Thus more work is needed here in order to understand whether or not VEGF-A based treatments are a viable path to improving aged skin function.
Human skin is ideally suited as a preclinical aging research model but is rarely used by mainstream aging research for this purpose. Yet, aging …
Researchers here report on an investigation of mechanisms by which aged human skin is improved in function when transplanted onto young immunocompromised mice. They identified VEGF-A as a factor involved in this improvement, and showed that delivering VEGF-A to human skin models can reduce signatures of aging. This is interesting, as a number of skin conditions exhibit high levels of VEGF-A, and are treated by therapies that are shown to inhibit VEGF-A in addition to other effects. Thus more work is needed here in order to understand whether or not VEGF-A based treatments are a viable path to improving aged skin function.
Human skin is ideally suited as a preclinical aging research model but is rarely used by mainstream aging research for this purpose. Yet, aging …